External preparation containing rapamycin

A technology of rapamycin and external preparations, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, and aerosol delivery, etc. Rapamycin deterioration and other problems
CN114585350APending Publication Date: 2022-06-03NOBELPHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NOBELPHARMA CO LTD
Publication Date
2022-06-03

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Abstract

The present invention addresses the problem of providing a rapamycin-containing external preparation which has excellent stability and is effective in the treatment of skin diseases. Provided is an external preparation containing (a) rapamycin, (b) at least one substance selected from the group consisting of ethylene glycol salicylate, diethyl sebacate, and glyceryl triacetate, and (c) propylene glycol and / or polyethylene glycol, also provided are: an external preparation which further contains an antioxidant; and an external preparation which further contains a lipophilic solvent solution of an antioxidant.
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Description

technical field

[0001] The present invention relates to an external preparation containing rapamycin. Specifically, it relates to an external preparation containing rapamycin, excellent in stability, and effective for the treatment of skin diseases. Background technique

[0002] Rapamycin (common name: sirolimus) is a macrolide produced by microorganisms. Rapamycin has an immunosuppressive effect, and thus has been used as a therapeutic drug for various diseases so far. For example, in addition to being used as an internal medicine for the treatment of lymphangioleiomyomatosis, in recent years, it is also used as an external preparation for the treatment of skin lesions accompanying tuberous sclerosis complex.

[0003] On the other hand, although rapamycin is soluble in some organic solvents including ethanol, it is hardly soluble in or hardly soluble in many solvents including water.

[0004] When using rapamycin as an external preparation, it is necessary to dissolve it...

Claims

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