Compound preparation prepared from clindamycin and cimetidine and preparation method
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A technology of clindamycin and compound preparations, which is applied in the field of medicine, can solve problems such as adverse reactions and poor curative effect of patients, and achieve the effects of enhancing curative effect, improving body immunity, and taking conveniently
Inactive Publication Date: 2022-06-14
王佑卿
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Problems solved by technology
However, clinical medication found that some patients have poor curative effect and severe gastrointestinal adverse reactions such as pseudomembranous colitis
Method used
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Embodiment 1
[0021] A compound formulation prepared by clindamycin and cimetidine, in the active ingredient of the compound preparation, the weight ratio of clindamycin and cimetidine is 0.075: 0.05, and the allowance is an excipient. The preparation method comprises the following steps:
[0022] (1) Weigh 75g of clindamycin API and 50g of cimetidine API, and spare;
[0023] (2) Take the appropriate amount of the required excipients suitable for the preparation of dry suspension and set aside;
[0024] (3) According to the preparation method of pharmacological dry suspension, the dry suspension is made, so that each generation contains clindamycin 150mg and cimetidine 100mg.
Embodiment 2
[0026] A compound formulation prepared by clindamycin and cimetidine, in which the weight ratio of clindamycin and cimetidine is 0.30: 0.20, and the residual amount is an excipient. The preparation method comprises the following steps:
[0027] (1) Weigh 30g of clindamycin API and 20g of cimetidine API, and set aside;
[0028] (2) Take the appropriate amount of the required excipients suitable for the preparation of the capsule and set aside;
[0029] (3) Make capsules according to the preparation method of pharmacy capsules, so that each capsule contains clindamycin 300mg and cimetidine 200mg.
[0030] Efficacy test
[0031] 1. Select the drugs prepared by Examples 1 and 2 and conduct clinical trials.
[0032] According to the parallel, randomized, controlled experimental design scheme, a control group is strictly set up to observe the clinical efficacy of the drugs prepared in Examples 1 and 2.
[0033] 2. Pathological selection
[0034] Inclusion of cases: Adult patients diagnos...
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Abstract
The invention provides a compound preparation prepared from clindamycin and cimetidine and a preparation method of the compound preparation. The clindamycin and cimetidine compound preparation comprises the active ingredients of clindamycin and cimetidine in a ratio of (0.075-1.2): (0.01-0.4). The preparation method comprises the following steps: taking the raw material medicines in corresponding parts, and adding proper auxiliary materials according to a corresponding preparation preparation method of pharmaceutics, so as to respectively prepare dosage forms such as granules, dry suspension, tablets, capsules, injection and the like. The action mechanism is that synthesis of bacterial protein is inhibited to generate an antibacterial effect, and the compound is mainly used for infection caused by gram-positive cocci and anaerobic bacteria. Cimetidine is a liver drug enzyme inhibitor and can delay metabolism of the combined drug and improve the blood concentration of the combined drug so as to improve the curative effect of the combined drug; meanwhile, cimetidine can also inhibit gastric acid secretion so as to relieve the stimulation of clindamycin to the stomach. The compound preparation prepared from the two medicines is used for treating infection caused by sensitive bacteria, and has the advantages of good effect, low side effect, safety in medication, convenience in taking and good application effect.
Description
Technical field [0001] The present application relates to the field of medical technology, in particular to a compound formulation prepared by clindamycin and cimetidine and a method of preparation thereof. Background [0002] Clindamycin, also known as chlorphenicol, is a derivative of lincomycin and has a good antibacterial effect on various types of gram-positive cocci and anaerobic bacteria. It is suitable for the treatment of respiratory infections, urinary tract infections, female pelvic and genital infections, skin and soft tissue infections, bone and joint infections, intra-abdominal infections caused by gram-positive and anaerobic bacteria. However, clinical medication has found that some patients have poor efficacy and have severe adverse reactions of the digestive tract such as pseudomembranous enteritis. Therefore, it is necessary to develop a combination preparation that can improve the efficacy of clindamycin and reduce its side effects, and use a safe and convenien...
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