Salt form of isoquinolinone compound as ROCK protein kinase inhibitor and preparation method thereof

A technology of compound and crystal form, which is applied in the field of salt form of isoquinolinone compound as a ROCK protein kinase inhibitor and its preparation, and can solve the problems of membrane permeability, pharmacokinetics, and druggability that need to be improved.
CN114644618APending Publication Date: 2022-06-21GUANGZHOU OCUSUN OPHTHALMIC BIOTECHNOLOGY CO LTD
2 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU OCUSUN OPHTHALMIC BIOTECHNOLOGY CO LTD
Publication Date
2022-06-21

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a salt form of an isoquinolinone compound serving as a ROCK protein kinase inhibitor and a preparation method of the salt form, and further discloses application of the salt form in preparation of drugs for treating glaucoma or intraocular hypertension diseases.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a salt form of an isoquinolinone-type compound as a ROCK protein kinase inhibitor and a preparation method thereof, and also includes the application of the salt form in the preparation of a medicine for treating glaucoma or ocular hypertension. Background technique

[0002] RHO-associated kinase (ROCK), a serine / threonine protein kinase, is a downstream target effector molecule of RHO and is widely expressed in the human body. RHO-related protein kinase (ROCK) is involved in the regulation of myosin light chain (MLC) and is suitable for the treatment of vasodilation. ROCK kinase can also act on trabecular outflow tract cells, relax trabecular cells, and reduce the outflow resistance of aqueous humor. The latest research shows that ROCK kinase inhibitors can also promote the damage and repair of corneal endothelial cells, prevent fibrosis, and have great application prospects.

[0003] Isoquinoline sulfonamide compounds are an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More