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Exhaled gas VOC (Volatile Organic Compounds) marker and detection system for distinguishing gastric cancer patient and gastritis patient

A technology of gastritis patients and markers, applied in the field of in vitro diagnostic reagents, can solve the problems of unclear metabolic mechanism of biomarkers, and achieve the effect of high detection sensitivity

Pending Publication Date: 2022-06-24
LIBEN HEALTHCARE (CHENGDU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, so far, since the metabolic mechanism of most of the screened biomarkers is not clear, there is no clear and effective clinical practice of exhaled breath markers applied to the screening of gastric cancer patients and gastritis patients.

Method used

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  • Exhaled gas VOC (Volatile Organic Compounds) marker and detection system for distinguishing gastric cancer patient and gastritis patient
  • Exhaled gas VOC (Volatile Organic Compounds) marker and detection system for distinguishing gastric cancer patient and gastritis patient
  • Exhaled gas VOC (Volatile Organic Compounds) marker and detection system for distinguishing gastric cancer patient and gastritis patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1. Gastric cancer detection by exhaled breath VOC markers of the present invention

[0034] 1. Subject information and exhaled breath collection:

[0035] The gastric cancer subjects and gastritis subjects involved in this study were all from the Affiliated Hospital of Air Force Military Medical University-Xijing Digestive Disease Hospital, and were clinically diagnosed with gastric cancer or gastritis. The healthy subjects in this study were recruited from the Analytical Instrument Research Center of Northwestern University. Our selection of gastric cancer, gastritis and healthy subjects was based on the following criteria: (1) 51 gastric cancer subjects: aged 18-75 years old, no gender restrictions; newly diagnosed patients with gastric cancer diagnosed by gastroscopy and tissue biopsy; no Treated with surgery, radiation, or chemotherapy. (2) 42 healthy subjects: aged 18-75 years old, no gender restrictions; good health; healthy people without gastrointestin...

experiment example 1

[0046] Experimental Example 1. ROC analysis results of exhaled breath markers of the present invention

[0047] 1. Experimental method

[0048] 9 markers (isopropanol, acetonitrile, 2-methyl-2-propanol, pentane, ethylbenzene, p-xylene, 2-methyl-decane, undecane, tridecane) were performed. Receiver operating characteristic curve (ROC) analysis was used to evaluate the diagnostic value of 9 markers and combined diagnosis.

[0049] 2. Experimental results

[0050] The ROC analysis results of each and the combined diagnosis of the 9 markers are as follows:

[0051] Table 2. ROC curve analysis results of nine gastric cancer exhaled breath markers

[0052]

[0053] According to Table 2, figure 2 The results show that the above-mentioned nine VOC markers in exhaled breath alone have the value of non-invasively distinguishing gastric cancer from gastritis and diagnosing gastric cancer.

[0054] In Table 2, LR represents the use of logistic regression to classify gastric cance...

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Abstract

The invention provides an exhaled gas VOC marker capable of effectively distinguishing a gastric cancer patient from a gastritis patient, and a detection system for distinguishing the gastric cancer patient from the gastritis patient based on the VOC marker. The VOC marker is any one or a combination of more of the following components: isopropanol, acetonitrile, 2-methyl-2-propanol, pentane, ethylbenzene, p-xylene, 2-methyl-decane, undecane and tridecane. Detection is carried out based on the VOC marker, high detection sensitivity and specificity are achieved, and a new means is provided for diagnosis and screening of gastric cancer.

Description

technical field [0001] The invention belongs to the field of in vitro diagnostic reagents, and particularly relates to an exhaled VOC marker and a detection system for distinguishing gastric cancer patients from gastritis patients. Background technique [0002] Gastric cancer is one of the common malignant tumors, and its morbidity and mortality ranks fifth and third in malignant tumors, respectively. The early diagnosis of gastric cancer is very important to effectively reduce the mortality of gastric cancer. However, the symptoms of early gastric cancer are very similar to gastritis, including upper abdominal discomfort, dull pain in the heart, and feeling of fullness after eating. greater difficulty. At present, most of the clinical methods used to identify the diagnosis of gastric cancer are expensive, radioactive, with low accuracy or invasiveness, and low patient compliance, which cannot meet the needs of large-scale gastric cancer screening. Therefore, there is an u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/30G01N30/72G06K9/62
CPCG01N30/02G01N30/30G01N30/72G06F18/241
Inventor 杨燕婷李先
Owner LIBEN HEALTHCARE (CHENGDU) CO LTD
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