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Controllable preparation of near-infrared luminous glutathione protected gold nano-cluster and luminous property regulation and control method of near-infrared luminous glutathione protected gold nano-cluster

A technology of gold nanoclusters and glutathione, which is applied in the fields of nanotechnology, luminescent materials, and nanotechnology for materials and surface science, can solve the problem of few types of near-infrared luminescent metal nanoclusters, limiting the application of nanomaterials, fluorescence Problems such as low quantum efficiency

Active Publication Date: 2022-07-01
JILIN UNIV
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Problems solved by technology

However, there are few types of near-infrared luminescent metal nanoclusters reported so far, and the fluorescence quantum efficiency is low and the luminescence range is not easy to control, which greatly limits the practical application of this type of nanomaterials.

Method used

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  • Controllable preparation of near-infrared luminous glutathione protected gold nano-cluster and luminous property regulation and control method of near-infrared luminous glutathione protected gold nano-cluster
  • Controllable preparation of near-infrared luminous glutathione protected gold nano-cluster and luminous property regulation and control method of near-infrared luminous glutathione protected gold nano-cluster
  • Controllable preparation of near-infrared luminous glutathione protected gold nano-cluster and luminous property regulation and control method of near-infrared luminous glutathione protected gold nano-cluster

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Experimental program
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Effect test

Embodiment 1

[0034] Preparation of glutathione-protected gold nanoclusters (AuNCs) by hydrothermal synthesis: chloroauric acid (HAuCl 4 ·3H 2 O) as Au source, glutathione (GSH) as ligand and sodium citrate as reducing agent. First, the effect of the dosage ratio of chloroauric acid and ligand glutathione on the luminescence of gold nanoclusters was investigated. First add 800μL, 10mM chloroauric acid solution to the stainless steel reaction kettle, and then according to the molar ratio of chloroauric acid and GSH 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1 : 8, 1:9, 1:10, respectively, add 100mM glutathione solution 160, 240, 320, 400, 480, 560, 640, 720, 800μL, then add 400μL, 500mM sodium citrate solution, and then supplement with distilled water The total reaction volume was 10 mL; the mixture solution was fully mixed, and the reaction kettle was transferred to an oven for 2 h and reaction temperature of 110 °C. After the reaction was cooled to room temperature, the product was measured by fluore...

Embodiment 2

[0037] Then, to explore the effect of the concentration of the reducing agent sodium citrate on the luminescence of gold nanoclusters, add 800 μL, 10 mM chloroauric acid solution, 320 μL, 100 mM glutathione solution to the stainless steel reaction kettle, and add 500 mM sodium citrate solution 80, 160 , 240, 320, 400, 480, 560, 640, 720, 800 μL, fully mix the mixture, transfer the reaction kettle to an oven, set a uniform reaction time of 2h, and a reaction temperature of 110°C. After the reaction is cooled to room temperature, pass Fluorescence spectroscopy measures the product.

[0038] The results showed that with the increase of sodium citrate concentration, the fluorescence emission peak at 805nm appeared and gradually increased until the final concentration of sodium citrate was 20mM, the fluorescence intensity decreased slightly. Therefore, 400 μL, 500 mM sodium citrate was chosen as the optimal concentration for gold nanocluster emission ( figure 2 ), the molar dosag...

Embodiment 3

[0040] Finally, the effects of reaction time and reaction temperature on the luminescence of gold nanoclusters were explored. 800 μL, 10 mM chloroauric acid solution, 320 μL, 100 mM glutathione solution, 400 μL, 500 mM sodium citrate were added to the stainless steel reaction kettle, and distilled water was added to make up The total reaction volume was 10 mL, the mixture was fully mixed, and the reaction kettle was transferred to an oven. 4.0h, after the reaction was cooled to room temperature, the product was measured by fluorescence spectroscopy.

[0041] The results showed that the fluorescence intensity of AuNCs@GSH obtained by reacting at 110 °C for 2.5 hours was the strongest ( image 3 ), the more suitable reaction time is 2.0-4.0h under the condition of 110℃;

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Abstract

The invention discloses controllable preparation of near-infrared luminous glutathione protected gold nanoclusters and a luminous property regulation and control method of the near-infrared luminous glutathione protected gold nanoclusters, and belongs to the technical field of controllable preparation of metal nanoclusters. According to the preparation method, HAuCl4. 3H2O is taken as an Au source, glutathione is taken as a ligand, sodium citrate is taken as a reducing agent, a near-infrared light-emitting gold nano-cluster is prepared through a hydrothermal synthesis method, then silver nitrate is added, and along with the addition of the silver nitrate, the particle size of AuNCs is increased and surface electron energy of the AuNCs is changed, so that the near-infrared light-emitting gold nano-cluster is obtained. Therefore, controllable preparation of the gold nano-cluster and continuous regulation and control of the fluorescence emission wavelength are realized. According to the method, the raw material dosage, the reaction temperature and the reaction time are optimized respectively, and the near-infrared luminous gold nanocluster (805nm) is successfully prepared; the introduction of Ag (I) ions can regulate and control the fluorescence emission performance of the gold nanocluster, the emission of AuNCs is transferred from 805 nm to 615 nm, and then the emission of AuNCs is subjected to red shift from 615 nm to 720 nm.

Description

technical field [0001] The invention belongs to the technical field of controllable preparation of metal nanoclusters, and in particular relates to a controllable preparation of near-infrared luminescence glutathione-protected gold nanoclusters and a method for regulating the luminescence properties thereof. Background technique [0002] Metal nanoclusters (MNCs) are a new class of ultra-small metal nanoparticles due to their unique photoluminescence properties (including good luminescence stability, good biocompatibility, tunable luminescence range and large Stokes shift, etc.) advantages), making it widely used in the fields of biosensing and bioimaging. Among them, gold nanoclusters (AuNCs) are the most widely and deeply studied typical nanoclusters, attracting more and more research interests. They have a typical core-shell structure, consisting of a metal core composed of several to hundreds of Au atoms and a shell of surface ligands. Studies have shown that the photo...

Claims

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Application Information

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IPC IPC(8): C09K11/58C09K11/02B82Y30/00
CPCC09K11/58C09K11/025B82Y30/00
Inventor 吴玉清李洪伟祁德燕
Owner JILIN UNIV
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