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Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating Alzheimer disease

A technology for Alzheimer's disease and a composition, applied in the field of medicine, can solve the problems of limited improvement of clinical symptoms and unsatisfactory long-term efficacy

Active Publication Date: 2022-07-12
ZHEJIANG WECOME MEDICINE IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drugs currently on the market are used to increase the level of acetylcholine, but the long-term efficacy is not ideal, and the improvement of clinical symptoms is limited. Therefore, finding a drug that can prevent and treat Alzheimer's disease has become an urgent problem in this field.

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating Alzheimer disease
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating Alzheimer disease
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating Alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Astragalus 20g, Pueraria Root 15g, Bupleurum 15g, Ganoderma lucidum 8g, Red Peony 15g, Turtle A 15g, Salvia 15g, Panax notoginseng 8g, Chickweed 15g, Yexiazhu 20g

[0041]The turtle shell and Ganoderma lucidum were extracted 3 times with 8 times the amount of water, each time for 3 hours, filtered, and the filtrate was combined for use; astragalus, salvia, pueraria, and Panax notoginseng were added with 8 times the amount of 70% ethanol to extract 3 times, 1 hour each time , filter, combine the filtrates, recover ethanol under reduced pressure at 60 °C, and set aside; Bupleurum chinensis, Chikusao, red peony root, and Radix Paeoniae Alba, add 8 times the amount of water to extract 3 times, 1 hour each time, filter, and the filtrate is the same as the aforementioned The two extracts were combined, concentrated to a thick paste with a relative density of 1.30-1.35 (50°C), dried under reduced pressure (60°C, -0.08Mpa), pulverized into fine powder, added an appropriate amoun...

Embodiment 2

[0043] Astragalus 20g, Pueraria Root 6g, Bupleurum 6g, Ganoderma lucidum 5g, Red peony 6g, Turtle A 6g, Salvia 10g, Panax notoginseng 5g, Chickweed 6g, Yexiazhu 20g

[0044] The turtle shell and Ganoderma lucidum were extracted 3 times with 8 times the amount of 70% ethanol, each time for 3 hours, filtered, and the filtrate was combined and set aside; Add 8 times the amount of 70% ethanol to extract the beads for 3 times, each time for 1 hour, filter, combine the filtrates, and recover the ethanol under reduced pressure at 60 °C for later use; combine the filtrates and concentrate to a thick paste with a relative density of 1.30-1.35 (50 °C). , dried under reduced pressure (60°C, -0.08Mpa), pulverized into fine powder, added lactose and starch in appropriate amount, mixed, granulated, dried, added with magnesium stearate, mixed, compressed, and coated to obtain tablets agent.

Embodiment 3

[0046] Astragalus 10g, Pueraria Root 10g, Bupleurum 10g, Ganoderma lucidum 10g, Red peony root 10g, Softshell turtle 10g, Salvia 10g, Panax notoginseng 10g, Chickweed 10g, Yexiazhu 10g

[0047] The turtle shell and Ganoderma lucidum were extracted 3 times with 8 times the amount of water, each time for 3 hours, filtered, and the filtrate was combined and set aside; Extract 3 times with 8 times the amount of water, 1 hour each time, filter, combine the filtrates and set aside; combine the filtrates, concentrate into a clear paste, add ethanol to make the alcohol content reach 65%, let stand and refrigerate overnight, take the supernatant, reduce Press to recover ethanol, add an appropriate amount of sodium saccharin, essence, sodium benzoate, sorbitol, and Tween-80, stir and mix evenly, add water to make the volume, and divide into packaging to obtain an oral liquid.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of a medicine for preventing and treating Alzheimer's disease. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-30 parts of astragalus membranaceus, 1-20 parts of radix puerariae, 1-20 parts of radix bupleuri, 1-10 parts of lucid ganoderma, 1-20 parts of radix paeoniae rubra, 1-20 parts of turtle shell, 1-20 parts of salvia miltiorrhiza, 1-10 parts of pseudo-ginseng, 1-20 parts of abrus cantoniensis hance and 1-30 parts of phyllanthus urinaria. The water-based or organic solvent extracts of the traditional Chinese medicines are pure natural components, are safer and have no obvious side effects. The traditional Chinese medicine composition overcomes the defect that the side effect of western medicine for preventing and treating the Alzheimer's disease is large, the advantage of overall adjustment of compound traditional Chinese medicine is exerted, and the traditional Chinese medicine composition has a good effect of preventing and treating the Alzheimer's disease and can be prepared into an economical and practical medicine for preventing and treating the Alzheimer's disease with a definite curative effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of a traditional Chinese medicine composition in the preparation of a medicine for preventing and treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a chronic neurodegenerative disease with insidious onset and progressive development, with memory impairment, language function and other cognitive decline as the main symptoms , can lead to the decline of patients' ability of daily life, abnormal mental behavior, and bring great burden to the family and society. AD has become an important public health problem worldwide. According to the 2019 World Alzheimer's Disease Report, the number of AD patients worldwide has reached 50 million, and it is expected to increase to 152 million in 2050. AD has become the fifth leading cause of death globally. [0003] At present, many speculations about the pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/65A61K36/71A61K9/16A61P25/28A61K35/586
CPCA61K36/481A61K36/488A61K36/233A61K36/074A61K36/71A61K36/65A61K35/586A61K36/537A61K36/258A61K36/48A61K36/47A61K9/1652A61P25/28A61K2300/00Y02A50/30
Inventor 孔晓霞王宗权丁京伟李艳英王国华
Owner ZHEJIANG WECOME MEDICINE IND
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