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Aggregation-induced emission material as well as preparation method and application thereof

A technology of aggregation-induced luminescence and light wavelength, which is applied in the fields of wave energy or particle radiation treatment materials, pharmaceutical formulations, medical preparations with inactive ingredients, etc. In situ clearance, reducing drug resistance, and the effect of tight connection

Pending Publication Date: 2022-07-15
THE THIRD PEOPLES HOSPITAL OF SHENZHEN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of this application is to provide an aggregation-induced luminescent material and its preparation method and application, aiming to solve the problem that the materials in the prior art cannot quickly label and sterilize bacteria

Method used

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  • Aggregation-induced emission material as well as preparation method and application thereof
  • Aggregation-induced emission material as well as preparation method and application thereof
  • Aggregation-induced emission material as well as preparation method and application thereof

Examples

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preparation example Construction

[0036] A method for preparing an aggregation-induced luminescent material provided in the second aspect of the embodiments of the present application includes the following steps:

[0037] S01. provide a D-alanine derivative containing a first unsaturated bond and a 4-(2-(4-diphenylmethylaminophenylethene) pyridinium bromide derivative containing a second unsaturated bond;

[0038] S02. Combine the D-alanine derivative containing the first unsaturated bond and the 4-(2-(4-benzylaminophenylvinyl)pyridine bromide derivative containing the second unsaturated bond) Mixing treatment and click chemistry reaction are performed to obtain aggregation-induced luminescent materials.

[0039] The second aspect of the embodiments of the present application provides a method for preparing an aggregation-induced luminescent material. The preparation method is simple and easy to operate. The D-alanine derivative containing the first unsaturated bond and the D-alanine derivative containing the...

Embodiment A1

[0063] A kind of aggregation-induced luminescent material and preparation method thereof

[0064] The provided aggregation-induced light-emitting material is 3-tetrazine-D-alanine and 1-trans-cyclooctene-4-(2-(4-diphenylmethylaminophenylethene) pyridinium bromide) linked by chemical bonds.

[0065] The preparation method of aggregation-induced luminescent material comprises the following steps:

[0066] to provide 3-tetrazine-D-alanine and 1-trans-cyclooctene-4-(2-(4-benzylaminophenylethene)pyridinium bromide in a molar ratio of 1:0.1,

[0067] 3-Tetrazine-D-alanine and 1-trans-cyclooctene-4-(2-(4-dibenzylaminophenylethene)pyridine bromide were mixed and processed, stirred and mixed at room temperature and A click chemistry reaction is performed to obtain an aggregation-induced luminescent material.

Embodiment A2

[0069] A kind of aggregation-induced luminescent material and preparation method thereof

[0070] The provided aggregation-induced light-emitting material is 3-tetrazine-D-alanine and 1-trans-cyclooctene-4-(2-(4-diphenylmethylaminophenylethene) pyridinium bromide) linked by chemical bonds.

[0071] The preparation method of aggregation-induced luminescent material comprises the following steps:

[0072] to provide 3-tetrazine-D-alanine and 1-trans-cyclooctene-4-(2-(4-benzylaminophenylethene)pyridinium bromide in a molar ratio of 1:1.5,

[0073] 3-Tetrazine-D-alanine and 1-trans-cyclooctene-4-(2-(4-dibenzylaminophenylethene)pyridine bromide were mixed and processed, stirred and mixed at room temperature and A click chemistry reaction is performed to obtain an aggregation-induced luminescent material.

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Abstract

The invention relates to the technical field of material synthesis, in particular to an aggregation-induced emission material and a preparation method and application thereof.The aggregation-induced emission material comprises a metabolic group and an aggregation-induced emission group which are connected through chemical bonds, the metabolic group comprises a D-alanine derivative containing a first unsaturated bond, and the aggregation-induced emission group comprises a D-alanine derivative containing a second unsaturated bond. The aggregation-induced emission group comprises a 4-(2-(4-diphenylmethylamine phenyl ethylene) pyridine bromide derivative containing a second unsaturated bond, rapid labeling and in-situ removal of bacteria are realized, and the aggregation-induced emission group has the characteristics of rapid detection, broad-spectrum antibacterial property, drug resistance reduction and the like, and has a wide application prospect in clinical treatment of bacteria, especially drug-resistant bacteria.

Description

technical field [0001] The present application belongs to the technical field of material synthesis, and in particular relates to an aggregation-induced luminescent material and a preparation method and application thereof. Background technique [0002] Before penicillin was discovered, countless people died from infection with pathogenic bacteria. In 1928, British scientist Fleming first discovered penicillin in experimental research. In 1943, penicillin was mass-produced, bringing dawn to the treatment of infectious diseases. With the discovery and mass production of more antibiotics such as streptomycin and vancomycin, the phenomenon of antibiotic abuse has become increasingly serious. The long-term, extensive and excessive clinical abuse of antibiotics has led to drug-resistant and multi-drug-resistant bacterial strains (“ The emergence of superbugs"). According to statistics, the nosocomial infection rate of multidrug-resistant strains is as high as 8%. Nosocomial in...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/54A61P31/04
CPCA61K41/0057A61K47/542A61P31/04
Inventor 廖明凤戴桂琴赵鹏飞张政郑明彬刘东京
Owner THE THIRD PEOPLES HOSPITAL OF SHENZHEN
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