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Hydrogel coating for Eustachian tube balloon dilatation catheter and preparation method thereof

A technique for dilating catheters and eustachian tubes, which is applied in the field of medical equipment, can solve the problems of complex reaction process and high equipment cost, and achieve the effects of improving lubrication effect, reducing production cost and improving safety

Active Publication Date: 2022-07-15
MAXENMED GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the ultraviolet light-induced reaction process is relatively complicated, and the equipment cost is relatively high.

Method used

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  • Hydrogel coating for Eustachian tube balloon dilatation catheter and preparation method thereof
  • Hydrogel coating for Eustachian tube balloon dilatation catheter and preparation method thereof
  • Hydrogel coating for Eustachian tube balloon dilatation catheter and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] The present embodiment provides a method for preparing a hydrogel coating for a Eustachian tube balloon dilation catheter, comprising the following steps:

[0043] (1) The Eustachian tube balloon catheter was treated with a plasma surface treatment machine for 20 minutes, and the treated Eustachian tube balloon catheter was placed in a citric acid aqueous solution for 30 minutes. The mass of citric acid in the citric acid aqueous solution The fraction was 3.5%; the soaked Eustachian tube balloon catheter was taken out and dried at 45°C;

[0044] (2) using a pulling device to dip and coat the sodium alginate aqueous solution on the surface of the Eustachian tube balloon catheter obtained in step (1), the pulling speed is fixed at 10 mm / min, and the mass fraction of sodium alginate in the sodium alginate aqueous solution is 10%, after the coating is completed, the Eustachian tube balloon catheter is dried in an oven at 95°C for 6h;

[0045] (3) Soak the Eustachian tube b...

Embodiment 2

[0047] The present embodiment provides a method for preparing a hydrogel coating for a Eustachian tube balloon dilation catheter, comprising the following steps:

[0048] (1) The eustachian tube balloon catheter was treated with a plasma surface treatment machine for 20 minutes, and the treated eustachian tube balloon catheter was placed in a malic acid aqueous solution for 60 minutes. The mass of malic acid in the malic acid aqueous solution The fraction is 2.0%; take out the soaked Eustachian tube balloon catheter and dry it at 50°C;

[0049] (2) using a pulling device to dip and coat the sodium alginate aqueous solution on the surface of the Eustachian tube balloon catheter obtained in step (1), the pulling speed is fixed at 10 mm / min, and the mass fraction of sodium alginate in the sodium alginate aqueous solution is 12%, after the coating is completed, the Eustachian tube balloon catheter is dried in an oven at 110°C for 4h;

[0050] (3) Soak the Eustachian tube balloon ...

Embodiment 3

[0052] The present embodiment provides a method for preparing a hydrogel coating for a Eustachian tube balloon dilation catheter, comprising the following steps:

[0053] (1) The eustachian tube balloon catheter was treated with a plasma surface treatment machine for 20 minutes, and the treated eustachian tube balloon catheter was placed in a succinic acid aqueous solution for 40 minutes, and the mass of succinic acid in the succinic acid aqueous solution was The score was 4.0%; the soaked Eustachian tube balloon catheter was taken out and dried at 50°C;

[0054] (2) using a pulling device to dip and coat the sodium alginate aqueous solution on the surface of the Eustachian tube balloon catheter obtained in step (1), the pulling speed is fixed at 10 mm / min, and the mass fraction of sodium alginate in the sodium alginate aqueous solution is 10%, after the coating is completed, the Eustachian tube balloon catheter is dried in an oven at 120°C for 3h;

[0055] (3) soaking the Eu...

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Abstract

The invention discloses a hydrogel coating for an Eustachian tube balloon dilatation catheter and a preparation method of the hydrogel coating, and belongs to the technical field of medical equipment. The method comprises the following steps: (1) performing oxygen plasma treatment on the Eustachian tube balloon dilatation catheter, soaking the Eustachian tube balloon dilatation catheter in a polycarboxylic acid solution, and then taking out and drying the Eustachian tube balloon dilatation catheter; (2) coating the surface of the Eustachian tube balloon dilatation catheter obtained in the step (1) with an alginate solution, and then drying the Eustachian tube balloon dilatation catheter; and (3) soaking the Eustachian tube balloon dilatation catheter obtained in the step (2) in a mixed solution of water-soluble chitosan and polycarboxylic acid, taking out the Eustachian tube balloon dilatation catheter, and drying the Eustachian tube balloon dilatation catheter to form the hydrogel coating. The hydrogel coating is used in cooperation with the Eustachian tube balloon dilatation catheter with the drug delivery function, and when the catheter enters a dry and narrow physiological cavity such as a diseased Eustachian tube, normal saline can be injected through the drug delivery function to wet the cavity, so that the lubricating effect of the hydrogel coating is improved.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a hydrogel coating for a balloon dilation catheter of the Eustachian tube and a preparation method thereof. Background technique [0002] Balloon dilatation catheter is a medical interventional device, which usually consists of multi-lumen tubing, balloon and multiple connectors. Balloons can be inflated in the body to dilate narrow physiological cavities in the body to achieve patency or to allow the passage of other devices. The balloon dilatation catheter was originally used as an interventional treatment device for stenotic coronary arteries, and its clinical application has been extended to the dilation of respiratory, digestive, excretory and reproductive tracts. Such physiological cavities shrink or even completely occlude due to lesions, inflammation, edema and other reasons. When the balloon dilatation catheter is inserted into or pulled out of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14A61M25/10A61M29/04A61L29/16
CPCA61M25/1027A61M29/02A61L29/085A61L29/145A61L29/16A61M2025/105A61M2207/00A61L2300/452A61L2300/41A61L2300/404A61L2300/236A61L2300/402A61L2300/606A61L2420/06C08L5/08C08L5/04
Inventor 郭淑儿郭绪欣
Owner MAXENMED GUANGZHOU
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