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Azelaic acid liposome whitening cream and preparation method thereof

A technology of azelaic acid lipid and cream, which is applied in the field of azelaic acid liposome whitening cream and its preparation, can solve problems such as erythema, itching, burning sensation, etc., and achieve increased transdermal absorption performance and improved stability Effect

Pending Publication Date: 2022-07-22
江苏华汀生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the topical application test in humans did not show systemic adverse reactions, some subjects still experienced side effects such as erythema, itching, and burning sensation after medication

Method used

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  • Azelaic acid liposome whitening cream and preparation method thereof
  • Azelaic acid liposome whitening cream and preparation method thereof
  • Azelaic acid liposome whitening cream and preparation method thereof

Examples

Experimental program
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Effect test

preparation example 1

[0041] Liposomes were prepared by the film hydration method routinely used by those skilled in the art, and 3 g of azelaic acid, 40 g of lecithin, 5 g of cholesterol and 1 g of DSPE-mPEG2000 were dissolved in chloroform methanol solution (chloroform:methanol=4:1V / V) , under reduced pressure and rotary evaporation at 37 °C to form a film; adding normal saline, hydrating at 37 °C for 2 hours, using an ultrasonic crusher to sonicate on ice; centrifuging at 18,000 g for 3 minutes, and then filtering with a 0.8 μm pore size filter to obtain a Diacid liposomes, the liposomes were redispersed in physiological saline to form a liposome solution (the concentration of azelaic acid was 3g / 100g).

preparation example 2

[0043] The preparation method and raw materials are the same as those of Preparation Example 1, and 5 g of azelaic acid is added to the preparation system, and the consumption of the remaining raw materials is the same as that of Preparation Example 1. Azelaic acid liposomes are prepared, and the liposomes are dispersed in physiological saline to form azelaic acid concentration. It is a 5g / 100g solution.

preparation example 3

[0045] The preparation method and raw materials are the same as those of Preparation Example 1. Add 7 g of azelaic acid to the preparation system, and the consumption of the remaining raw materials is the same as that of Preparation Example 1. Azelaic acid liposomes are prepared, and the liposomes are dispersed in physiological saline to form azelaic acid concentration. It is a 7g / 100g solution.

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Abstract

The invention discloses an azelaic acid liposome cream, the azelaic acid liposome cream comprises an azelaic acid liposome solution and a cream matrix, and the matrix comprises the following components in parts by mass: 20-100 parts of glycerin monostearate, 50-100 parts of liquid paraffin, 20-50 parts of stearic acid, 10-30 parts of white vaseline, 10-50 parts of glycerol, 10-20 parts of triethanolamine and 15-50 parts of water. The azelaic acid active component in the azelaic acid liposome solution exists in a form that the azelaic acid active component is free azelaic acid or DSPE-PEG-azelaic acid. Compared with the conventional free azelaic acid cream, the azelaic acid liposome cream provided by the invention has a good transdermal absorption effect, can remarkably inhibit the generation of skin melanin, and does not generate side effects on the skin.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, in particular to an azelaic acid liposome whitening cream and a preparation method thereof. Background technique [0002] Azelaic acid, also known as azelaic acid, generally exists in wheat, barley, etc. Azelaic acid contains two carboxyl groups, and the structural formula is It is generally used for the prevention and treatment of skin diseases, and has the effect of inhibiting or killing anaerobic and aerobic bacteria in the skin. The in vivo test showed that the topical application of azelaic acid cream for 2-3 months can significantly reduce the number of bacteria of the genus Propionibacterium in the skin and hair follicles, indicating that the azelaic acid cream has a direct antibacterial effect. [0003] In addition to antibacterial effects, studies have shown that azelaic acid selectively acts on abnormal melanocytes, inhibits melanin activity, and exerts a whitening effect. The mech...

Claims

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Application Information

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IPC IPC(8): A61K8/362A61K8/06A61K8/14A61K8/31A61K8/34A61K8/37A61K8/55A61K8/63A61K8/86A61Q19/02
CPCA61K8/362A61K8/375A61K8/31A61K8/345A61K8/553A61K8/63A61K8/86A61K8/06A61K8/14A61Q19/02A61K2800/82
Inventor 丁庆海
Owner 江苏华汀生物科技股份有限公司
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