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Preservative, preparation method thereof and cosmetic

A technology of preservatives and solvents, applied in the field of chemical material modification, can solve problems such as human skin damage

Pending Publication Date: 2022-07-22
에이앤에이치인터내셔널코스메틱스
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] This application provides a preservative, its preparation method and cosmetics, aiming to solve the problem of damage to human skin caused by traditional preservatives

Method used

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  • Preservative, preparation method thereof and cosmetic

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[0036] Preparation of preservatives

[0037] An embodiment of the second aspect of the present application provides a method for preparing a preservative, comprising the steps of:

[0038] (1) anisic acid and weak base are mixed and reacted in water to obtain anisic acid weak acid and weak base salt solution, and the weak base is selected from matrine, motherwort, lysine, arginine or its combination;

[0039] (2) obtain anisic acid weak acid and weak base salt from described anisic acid weak acid and weak base salt solution;

[0040] (3) Dissolving the weak acid and weak base salt of anisic acid in a solvent at a molar concentration of 0.02-0.1 mol / L to prepare the preservative.

[0041] In the embodiment of the present application, the mixing reaction of anisic acid and weak base in water in step (1) includes: adding anisic acid and weak base to water, and stirring for 0.5-1 h.

[0042] In some embodiments, the anisic acid and the weak base are mixed in water at a molar rat...

Embodiment 1

[0057] The present embodiment selects matrine to be used as a weak base, and the preparation of the preservative comprises the following steps:

[0058] Take matrine and add it to water, then add anisic acid, and the product generated by the reaction under stirring is anisic acid weak acid and weak base salt, the molar ratio of the two is 1:1, and the stirring time is 0.5-1h; the product after the reaction is reduced Press distillation, recrystallization and drying treatment; preferably vacuum drying treatment, the temperature is 40-50 ° C, drying for 12-24 hours; obtain solid powder of matrine anisate; take the solid powder mass fraction of 1.5% and dissolve in 1 , 2-pentanediol, to obtain the natural preservative of Example 1 (the molar concentration of matrine anisate is about 0.037mol / L).

Embodiment 2

[0060] The present embodiment selects leonurine to be used as a weak base, and the preparation of the preservative comprises the following steps:

[0061] Take Leonurine and add it into water, then add anisic acid, and the product generated by the reaction under stirring is anisic acid weak acid and weak base salt, the molar ratio of the two is 1:1, and the stirring time is 0.5-1h; the product after the reaction is decompressed Distillation, recrystallization and drying treatment; preferably vacuum drying treatment, the temperature is 40-50 ℃, drying for 12-24h; obtain solid powder of Leonurine anisate; take 1.5% of the solid powder mass fraction and dissolve in 1,2 - In pentanediol, the natural preservative of Example 2 is obtained (the molar concentration of leonurine anisate is about 0.032 mol / L).

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Abstract

The invention relates to a preservative, a preparation method thereof and cosmetics, the preservative comprises: (A) a salt of anisic acid and a weak base, the weak base being selected from matrine, leonurine, lysine, arginine or a combination thereof; (B) a solvent, and the molar concentration of the component (A) is 0.02-0.1 mol / L. According to the preservative provided by the invention, the anisic acid is dissolved in the solvent in the form of salt of the anisic acid and the weak base, so that the problem of low solubility of the anisic acid is solved, and the preservative effect of the anisic acid is enhanced. The preservative serving as a preservative of a natural source is used in cosmetics and does not cause damage to the skin of a human body.

Description

technical field [0001] The present application belongs to the technical field of chemical material modification, and in particular relates to a preservative, its preparation method and cosmetics. Background technique [0002] Preservatives are substances that have a sustained inhibitory effect on the growth of microorganisms. There are three general sources of preservatives: 1) aromatic alcohols, benzoic acid and its derivatives, aromatic ethers, isothiazolinones; 2) ethanol, essential oils, etc. Tea tree essential oil; Clove essential oil inhibits Gram-positive and Gram-negative bacteria, molds, and yeasts; 3) The ingredients of traditional Chinese medicine extracts also have antiseptic effect, which are commonly found in Compositae, Leguminosae, Liliaceae, Zingiberaceae, Rutaceae , Myrtaceae, Lauraceae, Cassia and so on. [0003] Preservatives are an essential ingredient in cosmetics. Cosmetic preservatives are mainly used to protect products from microbial contaminatio...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/34A61K8/41A61K8/44A61Q19/00
CPCA61K8/4926A61K8/41A61K8/44A61K8/49A61K8/345A61Q19/00A61K2800/10A61K2800/524A61K2800/805
Inventor 田勇沈洁袁菊懋牟沛松田云才江忠梅余涛
Owner 에이앤에이치인터내셔널코스메틱스
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