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Methods for identifying companion animals at risk of calcium oxalate calculus formation and treatments and compositions for reducing said risk

A calcium oxalate and stone technology, applied in biochemical equipment and methods, animal feed, animal feed, etc., can solve problems such as reducing the risk of calcium oxalate stones

Pending Publication Date: 2022-07-22
HILLS PET NUTRITION INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such diets are usually not sufficient to significantly reduce the risk of calcium oxalate stones

Method used

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  • Methods for identifying companion animals at risk of calcium oxalate calculus formation and treatments and compositions for reducing said risk
  • Methods for identifying companion animals at risk of calcium oxalate calculus formation and treatments and compositions for reducing said risk
  • Methods for identifying companion animals at risk of calcium oxalate calculus formation and treatments and compositions for reducing said risk

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0119] Preparation of the composition

[0120] The low arginine composition can be prepared as a food product suitable for consumption by cats. These food products can be of any consistency or moisture content; that is, the compositions can be wet, semi-moist or dry food products. "Wet" food products are typically those with a moisture content of 60% to 90% or greater. "Dry" food products are generally those with a moisture content of 3% to 11%, and are usually manufactured in the form of small pieces or kibble. A "semi-moist" food product typically has a moisture content of 25% to 35%. The food product may also contain components having more than one consistency, such as soft, chewy meat-like particles or pieces, and kibble with an outer cereal component or coating and an inner "cream" component.

[0121] Low-arginine food products can be prepared in canned or wet form using conventional food preparation processes known to those of ordinary skill in the art. Typically, gr...

example 1

[0130] A study was completed in which cats with the AG genotype were compared to cats with the homozygous GG genotype. The study used 34 cats and compared three diets. All foods were fed for one month, and at the end of the one-month feeding period, the cats' blood was analyzed for BAIB. Each cat consumed each food such that each cat had a blood sample from each food after a one-month feeding period.

[0131] Table 3 shows dietary concentrations of fiber and arginine (in percent).

[0132] table 3

[0133] diet fiber Arginine Fiber Increase, High Arginine 1.4 1.84 Fiber increased, low arginine 1.3 1.47 Low fiber, low arginine 0.9 1.44

[0134] Table 4 shows the relative BAIB concentrations of cats in the study. There were 17 cats per genotype.

[0135] Table 4

[0136] diet AG genotype GG genotype Fiber Increase, High Arginine 4.7 1.6 Fiber increased, low arginine 3.4 1.5 Low fiber, low arginine 3.7...

example 2

[0142]Blood was collected for determination of plasma metabolomic profiles. Plasma levels of BAIB and / or 2-oxoarginine can be measured by a commercial laboratory (Metabolon, Durham, NC, USA). The extracted supernatants were separated and run on gas chromatography and liquid chromatography mass spectrometer platforms. The peaks for each of BAIB and / or 2-oxoarginine are known, and the area under the peaks for each sample can be normalized to known samples. (See Evans, A.M. et al. (2009). Integrated, nontargeted ultrahighperformance liquid chromatography / electrospray ionization tandem mass spectrometry platform for identification and relative quantification of small molecule complements in biological systems (Integrated, nontargeted ultrahighperformance liquid chromatography / electrospray ionization) tandem massspectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems). Analytical Chemistry (Anal. Chem.) 81, 66...

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Abstract

Disclosed are methods of analyzing the presence of one or two copies of the minor allele A of SNP A 1212891692 in a biological sample obtained from a feline subject and / or the concentration of beta-aminoisobutyrate and / or 2-oxoarginine in said sample. The methods can be used in methods for identifying feline subjects with an increased likelihood or risk of calcium oxalate calculus formation and methods for treating feline subjects to reduce the risk of calcium oxalate calculus formation. The treatment comprises administering a low arginine diet to the feline subject. A low arginine feline food composition is disclosed.

Description

Background technique [0001] Bladder stones are relatively common in cats. Cats with conditions that affect the lower urinary tract, such as struvite or calcium oxalate bladder stones, usually have one or more symptoms such as urinating outside the litter box, straining to urinate, frequent urination, producing only a small amount of urine at any time fluid, blood in urine and licking of external genitalia. Results from abdominal X-rays and ultrasounds may lead to the discovery of bladder stones. Urinalysis results such as urine pH, presence of crystals, and presence of infection may lead to the diagnosis of calcium oxalate bladder stones. Bladder stones can be removed by surgery, cystoscopy (in female cats), or lithotripsy. A sample of the stone can be analyzed to confirm the diagnosis. [0002] Historically, bladder stones in cats have been composed of struvite, which is magnesium ammonium phosphate. To prevent struvite bladder stones, many feline diets are formulated so...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883A23K10/30A23K50/40G01N33/53
CPCC12Q2600/124C12Q2600/156C12Q1/6883G01N33/53G01N2800/50G01N2800/345G01N33/6812
Inventor 丹尼斯·朱厄尔杰弗里·布罗克曼伊登·伊弗雷姆马修·杰克逊
Owner HILLS PET NUTRITION INC
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