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Bioactive composition for preventing and/or treating retained fetal membranes of dairy cows, application of bioactive composition, powder and tablets

A biologically active and retained afterbirth technology is applied in the fields of biologically active compositions, powders and tablets for preventing and/or treating retained afterbirth of dairy cows, and can solve problems such as loss of milk production, hormone residues, antibiotic residues, etc. The effect of shortening the time, increasing the cure rate, and strong drug efficacy

Active Publication Date: 2022-08-05
HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the milk production of dairy cows during lactation is reduced by 753 kg / head due to retained placenta, and the annual loss of milk production, treatment loss and labor costs per head is $386, which has a significant impact on the dairy farming industry
At present, most aquaculture industries still use traditional methods to treat retained placenta, such as intramuscular injection of oxytocin, uterine perfusion of antibiotics, surgical stripping of afterbirth, and infusion of Chinese herbal medicine preparations. Although they have certain curative effects, they will also cause antibiotic residues and / or hormone residues and other disadvantages, bringing major hidden dangers to the breeding industry and food safety

Method used

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  • Bioactive composition for preventing and/or treating retained fetal membranes of dairy cows, application of bioactive composition, powder and tablets
  • Bioactive composition for preventing and/or treating retained fetal membranes of dairy cows, application of bioactive composition, powder and tablets
  • Bioactive composition for preventing and/or treating retained fetal membranes of dairy cows, application of bioactive composition, powder and tablets

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preparation example Construction

[0033] The present invention also provides a powder prepared by utilizing the biologically active composition, and the preparation method of the powder includes the following steps:

[0034] It is prepared by mixing liquiritin powder, lipoxygenase powder and paeonol powder.

[0035] The present invention also provides a tablet prepared by using the biologically active composition, and the preparation method of the tablet comprises the following steps:

[0036] (1) mixing the biologically active composition with an aqueous solution of ethyl cellulose, hydroxypropyl cellulose, lactose, and polyvinylpyrrolidone, and granulating to obtain Intermediate 1;

[0037] (2) adding sodium microcrystalline cellulose in intermediate 1, and granulating to obtain intermediate 2;

[0038] (3) magnesium stearate is added to intermediate 2, and tableting is performed to obtain tablets.

[0039] In the present invention, the mass ratio of the added mass of the ethyl cellulose to the bioactive c...

Embodiment 1

[0046] 1 kg of liquiritin powder, 800 g of lipoxygenase powder, and 700 g of paeonol powder were mixed, and pulverized to a particle size of 125 μm to obtain a powder.

Embodiment 2

[0048] 2 kg of liquiritin powder, 1.2 kg of lipoxygenase powder, and 300 g of paeonol powder were mixed, and ground to a particle size of 75 μm to obtain a biologically active composition.

[0049] Mix the above biologically active composition with 350g ethyl cellulose, 140g hydroxypropyl cellulose, 210g lactose, 350mL 10wt% polyvinylpyrrolidone aqueous solution, and granulate to obtain intermediate 1; add 140g microcrystalline cellulose to intermediate 1 Sodium, granulate to obtain intermediate 2; add 70 g of magnesium stearate to intermediate 2, and press into tablets to obtain tablets. Each piece weighs 6g / piece.

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Abstract

The invention relates to a bioactive composition for preventing and / or treating retained fetal membranes of dairy cows, application of the bioactive composition, powder and tablets, and belongs to the technical field of veterinary drugs. The bioactive composition disclosed by the invention is prepared from the following components in parts by mass: 10 to 20 parts of liquiritin powder, 8 to 12 parts of lipoxygenase powder and 3 to 7 parts of paeonol powder. The three components in the bioactive composition are indispensable, the three components are compatible to prepare the medicament, and when the medicament is used for treating retained fetal membranes of dairy cows, the medicament has the advantages that the medicament effect is strong, the cure rate is obviously increased, and the fetal membrane discharging time is obviously shortened compared with a medicament which is independently used or is prepared from any two components. The cure rate can reach 90% or above, and the afterbirth discharging time can be shortened to 48.3 h.

Description

technical field [0001] The present invention relates to the technical field of veterinary medicine, in particular to a biologically active composition for preventing and / or treating retained placenta of dairy cows and its application, a powder and a tablet. Background technique [0002] Retained placenta (RP), also known as retained placenta in dairy cows, refers to a reproductive disorder in dairy cows that fails to discharge the placenta normally and completely within 12 hours after giving birth. According to reports, retained placenta can cause pyometra and uterine Reproductive disorders such as endometritis can cause septicemia in dairy cows in severe cases, and can also lead to prolonged calving intervals, reduced milk production, and delayed uterine involution. In addition, the milk production of dairy cows during lactation is reduced by 753 kg / head due to the afterbirth, and the annual loss of milk production, treatment loss and labor cost per cow is $386, which has a...

Claims

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Application Information

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IPC IPC(8): A61K38/46A61K9/14A61K9/20A61P15/00A61K31/12A61K31/7048
CPCA61K38/465A61K31/12A61K31/7048A61K9/14A61K9/2054A61P15/00C12Y301/01003A61K2300/00
Inventor 鲁文赓原冬伟许美花孙宏亮金吉东
Owner HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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