Biological-friendly myocardial dressing as well as preparation method and application thereof

A kind of heart-friendly technology, applied in medical science, prosthesis, etc., can solve the problems of cytotoxicity of cross-linking agent, complicated raw materials of myocardial patch, easy to affect postoperative safety, etc., achieve good biocompatibility, reduce Immunogenicity and local inflammatory response, effect of improving biomechanical properties

Active Publication Date: 2022-08-09
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems that the existing myocardial patch has complicated raw materials, the cross-linking agent has cytotoxicity, and easily affects the safety after operation, the present invention provides a bio-friendly myocardial dressing and its preparation method and application

Method used

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  • Biological-friendly myocardial dressing as well as preparation method and application thereof
  • Biological-friendly myocardial dressing as well as preparation method and application thereof
  • Biological-friendly myocardial dressing as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] This embodiment provides a bio-friendly myocardial dressing, the myocardial dressing includes a fat decellularized matrix hydrogel and a myocardial patch.

[0037] In this example, the fat acellular matrix hydrogel contains the following components by mass: 20 parts of fat acellular matrix, 15 parts of gelatin and 165 parts of deionized water.

[0038] In this example, the myocardial patch contains the following components by mass: 100 parts of fat decellularized matrix, 15 parts of gelatin and 3 parts of procyanidin cross-linking agent.

[0039] This embodiment further provides a preparation method of a bio-friendly myocardial dressing.

[0040] The adipose tissue used in this example comes from the discarded mediastinal adipose tissue of patients undergoing coronary artery bypass surgery (informed consent has been signed before the operation). All solutions used were prepared in deionized water, i.e., they all contained 100 U / mL penicillin and 0.1 mg / mL streptomycin....

Embodiment 2

[0053] This embodiment provides a bio-friendly myocardial dressing, the myocardial dressing includes a fat decellularized matrix hydrogel and a myocardial patch.

[0054] In this example, the fat decellularized matrix hydrogel contains the following components by mass: 20 parts of fat acellular matrix, 5 parts of gelatin and 175 parts of deionized water.

[0055] In this example, the myocardial patch contains the following components by mass: 100 parts of fat decellularized matrix, 5 parts of gelatin and 0.1 part of procyanidin cross-linking agent.

[0056] This embodiment further provides a preparation method of a bio-friendly myocardial dressing.

[0057] The adipose tissue used in this example comes from the discarded mediastinal adipose tissue of patients undergoing coronary artery bypass surgery (informed consent has been signed before the operation). All solutions used were prepared in deionized water, i.e., they all contained 100 U / mL penicillin and 0.1 mg / mL streptomy...

Embodiment 3

[0067] This embodiment provides a bio-friendly myocardial dressing, the myocardial dressing includes a fat decellularized matrix hydrogel and a myocardial patch.

[0068] In this example, the fat acellular matrix hydrogel contains the following components by mass: 20 parts of fat acellular matrix, 15 parts of gelatin and 165 parts of deionized water.

[0069] In this example, the myocardial patch contains the following components by mass: 100 parts of fat decellularized matrix, 15 parts of gelatin and 1 part of catechin cross-linking agent.

[0070] This embodiment further provides a preparation method of a bio-friendly myocardial dressing.

[0071] The adipose tissue used in this example comes from porcine mediastinal adipose tissue, and the following operations are performed under aseptic conditions and strictly follow the principle of aseptic operation. All solutions used were prepared in deionized water, i.e., they all contained 100 U / mL penicillin and 0.1 mg / mL streptomy...

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Abstract

The invention relates to a bio-friendly myocardial dressing as well as a preparation method and application thereof, and belongs to the field of biomedical materials. In order to solve the problems that an existing myocardial patch is complex in raw material, a cross-linking agent has cytotoxicity, and postoperative safety is easily affected, the invention provides a biological friendly myocardial dressing which comprises fat acellular matrix hydrogel and / or a myocardial patch, the fat acellular matrix hydrogel takes fat acellular matrix as a main raw material, and the cross-linking agent has cytotoxicity. The myocardial local compliance can be improved; a plant-derived polyphenol cross-linking agent and fat acellular matrix hydrogel are subjected to cross-linking and freeze-drying to prepare the myocardial patch, and the myocardial patch can support diseased myocardium. The two can be used independently and can also be used in a combined manner, and the combined use can give consideration to the effects of mechanical support and myocardial local compliance improvement. The composition of the raw materials is safe and reliable, immunogenicity and local inflammatory response are reduced to the maximum extent, and good biocompatibility is achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a bio-friendly myocardial dressing and a preparation method and application thereof. Background technique [0002] At present, acute myocardial infarction is still one of the major diseases that threaten human health worldwide. According to statistics, the mortality rate of acute myocardial infarction among urban and rural residents in my country can reach 58.90 to 76.04 / 100,000. In recent years, with the continuous development, popularization and decline of percutaneous coronary intervention (PCI) and other technologies, more and more primary patients can receive revascularization treatment in a timely manner, but the mortality rate of patients is still high. No less. Many literatures have reported that a considerable number of patients undergoing emergency PCI still face the risk of long-term heart failure. This may be due to the fact that revascularization the...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/22A61L27/36A61L27/50A61L27/54A61L27/56
CPCA61L27/222A61L27/3604A61L27/50A61L27/3687A61L27/3691A61L27/54A61L27/56A61L2300/216A61L2300/416A61L2300/41A61L2300/426Y02A50/30
Inventor 康凯展旭曲辉邱冬云张国富
Owner HARBIN MEDICAL UNIVERSITY
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