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Method for improving blood compatibility of resin by using PEG (Polyethylene Glycol) as spacer arm

A spacer arm, resin technology, applied in chemical instruments and methods, other chemical processes, ion exchange, etc., can solve problems such as gas embolism, inability to return blood, and unsatisfactory improvement in actual effects, to improve compatibility and increase swing. Sex, prevent the effect of not being able to return blood

Inactive Publication Date: 2022-08-09
江苏恰瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During hemoperfusion treatment, the blood runs outside the body, and the adsorption material has a large area of ​​contact with the blood for a long time. If the compatibility between the adsorption material and the blood is insufficient, it will cause blood coagulation, resulting in failure to return blood, blockage, and gas during the treatment process. Consequences such as embolism
Therefore the premise of hemoperfusion success is the anticoagulant problem, and the method for solving the problem in the hemoperfusion mainly is to introduce polystyrene resin chloromethylation chloromethyl functional group at present, then introduce heparin with anticoagulant activity, as CN103611504A, but The actual effect improvement is not ideal

Method used

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  • Method for improving blood compatibility of resin by using PEG (Polyethylene Glycol) as spacer arm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Activation: take 6.0 g of chloromethylated polystyrene resin, rinse with 40 g / L NaOH solution for 4 hours, and then wash off the alkali solution with water to obtain an activated resin.

[0042] (2) put the resin treated in step (1) into the there-necked flask with condenser, soak 12h with 50mL toluene, fully swell, then add 36mmol PEG200, anhydrous potassium carbonate 5g, tetrabutylammonium bromide 0.5g, The reaction was stirred at 90° C. for 12 h. After the reaction was completed, rinsed with absolute ethanol for 5 times, rinsed with deionized water, and dried in vacuum to obtain PEG-resin (PEG loading amount was 0.156 g / g).

[0043] (3) Dissolve 50 mg of heparin sodium in 40 mL of water, stir evenly, and adjust to acidity with 2 mmol / L hydrochloric acid.

[0044] (4) Dissolve 40 g of dicyclohexylcarbodiimide (DDCI) in 10 mL of tetrahydrofuran, stir evenly, and pour it into the heparin sodium solution in step (3).

[0045] (5) Add the PEG-resin of step (2) to the...

Embodiment 2

[0059] The preparation of heparin-PEG-resin is the same as in Example 1, except that the PEG-resin is prepared by the following method:

[0060] (1) Take 10g of chloromethylated polystyrene resin and 3g of solid sodium hydroxide and put it in excess 120mL of PEG200.

[0061] (2) The first microwave irradiation was carried out according to the power of 600W, the temperature of 170°C, and the time of 15min.

[0062] (3) After the first microwave irradiation, cool to room temperature, repeat the microwave irradiation once, and filter with suction after cooling.

[0063] (4) Rinse with deionized water, 2mol / L hydrochloric acid, and methanol in turn, and cycle washing for 4-5 times.

[0064] (5) PEG-resin (PEG loading amount is 0.185g / g) is obtained after drying.

Embodiment 3

[0066] The difference from Example 1 is that PEG200 is replaced by PEG400.

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Abstract

The invention discloses a method for improving the blood compatibility of resin by taking PEG (polyethylene glycol) as a spacer arm. The method comprises the following steps: (1) grafting polyethylene glycol to adsorption resin to obtain PEG-resin; and (2) carrying out a reaction on the heparin sodium and the PEG-resin to obtain the heparin-PEG-resin. Compared with the prior art that the heparin is directly connected to the resin, the polyethylene glycol is used as a spacer arm for connecting the heparin and the resin, so that the compatibility of the resin and the blood can be remarkably improved, and the consequences of incapability of blood return, blockage, gas embolism and the like caused by insufficient compatibility of the resin and the blood in the treatment process can be effectively prevented.

Description

technical field [0001] The invention belongs to the field of adsorption materials, in particular to a method for improving the blood compatibility of resin with PEG as a spacer arm. Background technique [0002] Blood perfusion is to draw the patient's blood out of the body, and the blood enters the perfusion device through the pipeline. The perfusion device is equipped with an adsorbent material, and the adsorption capacity of the adsorbent material or other active substances immobilized on the adsorbent material is used to purify the blood. The commonly used adsorbent resin is polystyrene. During hemoperfusion therapy, the blood runs outside the body, and the adsorption material is in contact with the blood in a large area for a long time. If the compatibility of the adsorption material with the blood is insufficient, it will cause coagulation, resulting in failure to return blood, blockage, and gas during the treatment process. Embolism and other consequences. Therefore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30B01D15/08
CPCB01J20/265B01J20/30B01D15/08
Inventor 张俊峰张令慧周友浪
Owner 江苏恰瑞生物科技有限公司
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