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Degradable chemically crosslinked aquagel and its prepn

A chemical cross-linking and hydrogel technology, which is applied in the field of chemical cross-linking hydrogel and its preparation, can solve the problems of difficulty in uniformity and inconvenient cross-linking reactions, and achieve a wide range of biomedical applications, simple equipment, and easy operation Simple and convenient effect

Inactive Publication Date: 2004-11-24
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is inconvenient to use photoinitiation for tissue engineering and other occasions that need to be injected into the body; for larger gels, it is difficult to achieve uniformity in light and the resulting cross-linking reaction

Method used

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  • Degradable chemically crosslinked aquagel and its prepn
  • Degradable chemically crosslinked aquagel and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1, the molar ratio of the reactants is PEG10K: L-lactide: stannous octoate = 1:32:0.02 (for the description of PEG10K and other codes, see the last "Note"), after mixing evenly, vacuumize at 60°C 6 hours to remove volatile matter, then replace with inert gas (nitrogen or argon) several times, and finally heat seal the ampoule tube under vacuum (0.1 mmHg). The copolymerization reaction was carried out at 140° C. for 24 hours. The dichloromethane solution of the copolymerization product is reacted with acryloyl chloride (molar ratio: 1:10), filtered after the reaction, and the filtrate is precipitated in anhydrous ether (-10~0°C), the precipitate is collected, and vacuum-dried to obtain a macromonomer PEG10K-L32. In this macromonomer phosphate buffer solution (PBS) with a weight concentration of 30%, add a redox initiator ammonium persulfate with a weight concentration of 2%, chemically cross-link at 37° C. to obtain a hydrogel. After the hydrogel reached swelli...

Embodiment 2

[0025] Embodiment 2, operation is the same as embodiment 1, and reactant molar ratio is PEG8K: ε-caprolactone: D, L-lactide: stannous octoate=1: 2: 2: 0.02, obtain macromolecular monomer PEG10K-CL2-DL2. Add redox initiator ammonium persulfate with a weight concentration of 2% to the macromer PBS solution with a weight concentration of 40%, and chemically cross-link at 37° C. to obtain a hydrogel. After the hydrogel reached swelling equilibrium in PBS solution at 37°C, the water absorption rate was 92%, and the volume swelling ratio was 3.5.

Embodiment 3

[0026]Embodiment 3, operation is the same as embodiment 1, the molar ratio of reactant feeding is PEO-PPO-PEO (block length ratio is EO: PO: EO=99: 65: 99): glycolide: stannous octoate=1 :8:0.02, the macromer PEO-PPO-PEO-G8 was obtained. The macromonomer PBS solution with a weight concentration of 30% was added with a redox initiator potassium persulfate with a weight concentration of 1%, and chemically cross-linked at 37° C. to obtain a hydrogel. After the hydrogel reached swelling equilibrium in PBS solution at 37°C, the water absorption rate was 80%, and the volume swelling ratio was 2.4.

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Abstract

The present invention relates to the field of polymer material, and especially a degradable chemically crosslinked hydrogel and its preparation. Completely or partially hydrophilic macro molecular compound or oligomer as main component as well as degradable oligomer forms hydrogel at body temperature or room temperature in aqueous phase through one macromolecular monomer process. The hydrogel can not be dissolved in water and may be degraded controllably, so that it may be used as tissue or cell culture rack, medicine controlled-release carrier, etc. in biological material field.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a chemically cross-linked hydrogel with degradation properties and a preparation method thereof. technical background [0002] The degradation products of polymers with degradative properties are low molecular weight compounds or eventually metabolized into small molecular compounds such as CO 2 and H 2 O et al. If the degradation product is water-soluble, it can be directly excreted or absorbed by the body through various metabolic processes; if the degradation product is insoluble in water and has a large molecular weight, it can be further degraded by lysosomes through the phagocytosis of macrophages, thus May cause sterile inflammatory reaction and has certain toxicity. [0003] Biodegradable polymers have been widely used in the medical field (such as medical sutures, bone nails, plastic surgery and medicine, etc.) and as drug carriers to achieve con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075
Inventor 丁建东朱文张俊川
Owner FUDAN UNIV