Preparation method of isoflurane

A technology of isoflurane and trifluoroethanol, which is applied in the field of preparation of 1-chloro-2, organic compounds, can solve the problems of high impurity content in the final product, difficulty in ensuring the yield of isoflurane, and difficulty in achieving repeated rectification, etc. Achieve the effects of easy quality control, improved yield and stable operation

Active Publication Date: 2006-09-27
LUNAN PHARMA GROUP CORPORATION
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the range of reaction conditions in this route is too wide, it is difficult to ensure the yield of isoflurane, and the impurity content of the final product is relatively high, and repeated rectification is also difficult to meet the requirements of the standard.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of isoflurane
  • Preparation method of isoflurane
  • Preparation method of isoflurane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the preparation of 2,2,2-trifluoroethyl difluoromethyl ether

[0020] Add 200g of TFE and 80g of NMP into the autoclave, close the autoclave, start stirring, add 173g of Freon-22 (F-22), then fill the autoclave with nitrogen, add 368g of 50% NaOH aqueous solution at 5°C under stirring, and control The temperature in the autoclave is between 36°C, after the addition, fill the autoclave with nitrogen to 18-20kg / cm 2 , stirred for 3 hours. Transfer the reaction solution in the still to the distillation still, heat and fractionate in a water bath with stirring, collect fractions below 30°C to obtain CF 3 CH 2 OCHF 2 180g, the residue continued to distill, reclaimed TFE60.5g, conversion rate was 60%, and yield was 86% (according to the TFE consumption calculation).

Embodiment 2

[0021] Embodiment 2: the preparation of isoflurane

[0022] Put 300g (2.0mol) 2,2,2-trifluoroethyl difluoromethyl ether into the chlorination tank, turn on the stirring and fluorescent lamp, and feed a small amount of chlorine gas. When the color of the chlorine gas in the tank disappears, use a gas flow meter to control The speed of passing chlorine gas makes it react completely without overflowing. The water bath controls the reaction temperature at 15-20° C., feeds 0.9 mol of chlorine gas, and then reacts at 15-20° C. for 30 minutes. The reaction liquid was distilled, and the fraction below 40°C was collected as the etherified product to obtain 150 g. Cool the residue to 5-10°C, slowly add sodium hydroxide solution dropwise under stirring, stir for 10 minutes after adding, let stand for 10 minutes, put the lower layer chloride solution into the storage tank, wash it with water three times, and remove the lower layer chloride solution The solution was put into a drying tan...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A process for preparing isolfuothane from trifluoroethanol, N-methypyrrolidone and freon-22 includes such steps as etherifying and chloridizing.

Description

technical field [0001] The invention relates to a preparation method of an organic compound, in particular to a preparation method of 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (ie isoflurane), and belongs to the field of medicine and chemical industry. Background technique [0002] Isoflurane is a general inhalational anesthetic and is the isomer of enflurane. Animal experiments and clinical studies have shown that isoflurane has low biochemical transformation, low liver and kidney toxicity, small circulation inhibition, good muscle relaxation, rapid and stable induction and recovery, no spasmodic brain waves, good recovery and small side effects, etc. advantage. [0003] There are many preparation methods of isoflurane reported in the literature, but the process conditions are relatively complicated, the synthesis route is long, and the cost is high. U.S. Patent US3535425 (1970) discloses a kind of preparation method of isoflurane, and its reaction route is: [...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07C43/12C07C41/01
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap