Slow-releasing micro-balls of demethyl cantharidine, and its prepn. method

Abstract

A biodegradable slow-release micro-sphere of norcantharidin is prepared from a biodegradable polymer as carrier and norcantharidin as active component through mixing the solution of said polymer in dichloromethane or ethyl acetate with the aqueous solution of norcantharidin containing surfactant, stirring, adding it to the aqueous solution containing polyvinyl alcohol, stirring or evaporation, dialysis and freeze drying.

Description

technical field

[0001] The invention belongs to the technical field of nanomaterials and biomedicine, and in particular relates to a preparation method of norcantharidin sustained-release microspheres. Background technique

[0002] Norcantharidin is a new type of anti-tumor drug first synthesized in my country. It also has the functions of increasing white blood cells, protecting liver cells, and regulating immunity, so it has been paid more and more attention. It is believed that with the development of molecular biology techniques, the molecular mechanism of its anticancer effect will be gradually elucidated. However, because norcantharidin still has certain organ toxicity, its clinical dose is limited, which affects the anticancer effect; Cantharidin is an effective way to further popularize and use. A large number of data show that high encapsulation rate and small particle size are necessary conditions for reducing toxicity and improving curative effect. At present, t...