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Method for increasing content of flavone in extracting ginkgo leaves by using affinity ultrafiltration

A technology of ginkgo biloba leaves and extracts, which is applied in the field of ultrafiltration of ginkgo biloba extracts with functional affinity ultrafiltration membranes, and can solve the problems of unsatisfactory separation selectivity of ultrafiltration membranes and the like.

Inactive Publication Date: 2007-07-25
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The separation mechanism of the ultrafiltration membrane is mainly distinguished by the molecular size, so when the molecular weight difference between the target substance and the impurity to be separated is not large, the separation selectivity of the ultrafiltration membrane is not ideal

Method used

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  • Method for increasing content of flavone in extracting ginkgo leaves by using affinity ultrafiltration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A PVDF flat membrane with a diameter of 20cm is immersed in 1% KMnO 4 and 500mL of a mixed solution of 1.0mol / L KOH, react at 60°C for 12min, take out the membrane and rinse it with distilled water, wash off the residual reaction solution on the surface, and immerse in 1.0% acidic NaHSO 3 Rinse in the solution until the surface of the film returns to white, then immerse the film in a 3.0% polyvinylpyrrolidone (PVP) solution, soak for 30 minutes at 30°C, then take the film out and dry it in a vacuum oven for 15 minutes at a drying temperature of 40°C. After the end, the samples were taken for analysis, mainly measured by FTIR (infrared spectroscopy) and EA (elemental analysis). 4 After reacting with 500 mL of 1.0 mol / L KOH mixed solution, the final elemental analysis results showed (see Table 1) that the ratio of the moles of PVP to the moles of the base film itself with vinyl as the unit was 1:16.

Embodiment 2

[0020] A PVDF flat membrane with a diameter of 20cm is immersed in 0.2% KMnO 4 and 500mL of a mixed solution of 0.3mol / L KOH, react at 40°C for 6min, take out the membrane and rinse it with distilled water, wash off the residual reaction solution on the surface, and immerse in 1.0% acidic NaHSO 3 Rinse in the solution until the surface of the film returns to white, then immerse the film in 0.5% polyvinylpyrrolidone (PVP) solution, soak at 30°C for 30min, then take the film out and dry it in a vacuum oven for 20min at a drying temperature of 40°C. After the end, the samples were taken for analysis, mainly measured by FTIR (infrared spectroscopy) and EA (elemental analysis). 4 After reacting with 500mL of the mixed solution of 0.3mol / L KOH, the final elemental analysis results showed (see Table 1) that the ratio of the moles of PVP to the moles of the base film itself with vinyl as the unit was 1:400.

Embodiment 3

[0022] A PVDF flat membrane with a diameter of 20cm is immersed in 5% KMnO 4 and 500mL of a mixed solution of 5mol / L KOH, react at 70°C for 12min, take out the membrane and rinse it with distilled water to wash off the residual reaction solution on the surface, and immerse it in 3.0% acidic NaHSO 3 Rinse in the solution until the surface of the film returns to white, then immerse the film in a 3% polyvinylpyrrolidone (PVP) solution for 60 minutes at 30°C, then take the film out and dry it in a vacuum oven for 20 minutes at a temperature of 60°C. Sampling after the analysis is mainly carried out by FTIR (infrared spectroscopy) and EA (elemental analysis). 4 After reacting with 500mL of the mixed solution of KOH of 5mol / L, the final elemental analysis results showed (see Table 1) that the ratio of the moles of PVP to the moles of the base film itself with vinyl as the unit was 1:5.8. However, the modified membranes produced under such conditions are easily damaged in ultrafiltr...

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Abstract

An affinity ultrafiltration method for increasing the content of flavone in the extract of ginkgo leaf includes such steps as immersing the ultrafiltration membrane made of polyvinylidene difluoride in the aqueous solution of KMnO4 containing KOH, heating, water washing, rinsing in acidic solution of NaHSO3, immersing in polyvinyl pyrrolidone, vacuum drying, immersing in water for future use, dissolving the coarse extract of gingko leaf in aqueous solution of alcohol, microfiltering, ultrafiltering by the ultrafiltration membrane made of sulfonated polyethersulfone, regulating pH=7.5-8.8, affiniting ultrafiltering by above-said ultrafiltration membrane, vacuum distilling of intercepted liquid, and vacuum drying.

Description

1. Technical field [0001] The invention relates to a method for ultrafiltering ginkgo biloba extract with a functional affinity ultrafiltration membrane to increase the flavonoid content in the extract. 2. Background technology [0002] Ginkgo biloba is the leaf of Ginkgo biloba (Ginkgo Biloba). Ginkgo biloba is a special product of our country and one of the existing ancient relic plants. Ginkgo biloba contains bioactive components such as flavonoids and terpenoids. These ingredients have quite strong anti-oxidation effects, can remove excess free radicals in organisms, prevent lipid peroxidation in tissues, and improve the immunity of the human body. They are the natural medicines of choice for the treatment of cardiovascular and cerebrovascular diseases. Over the past ten years, a lot of research work has been done on the development and utilization of this resource at home and abroad. According to reports, the main flavonoids quercetin, kaempferol, and isorhamnetin in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61P39/06A61P9/00A61K127/00
Inventor 张志炳徐志红李磊武法文谭淑娟
Owner NANJING UNIV
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