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Technological process of producing orotic acid

A process method and orotic acid technology, applied in the direction of organic chemistry, can solve the problems of corrosion and reduce the production cost of orotic acid, so as to reduce the cost, reduce the corrosion and pollution of the environment and equipment, and reduce the pressure of the environment. Effect

Inactive Publication Date: 2002-01-23
SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to solve the corrosion problem of using elemental bromine in the production of orotic acid and reduce the production cost of orotic acid

Method used

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  • Technological process of producing orotic acid

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Effect test

Embodiment 1

[0023] The preparation of embodiment 1 BDHPCA

[0024] Put 320g of sodium bromide into 1000ml of water, heat, feed chlorine gas, and react with a mixture of 158g of maleuride and 1200ml of water at 0-15°C. The reaction takes about 5-10 hours, and the solid BDHPCA is obtained by filtering and washing. The product does not need to be further dried and purified, and can be directly used in the next reaction. Yield 93%.

Embodiment 2

[0025] Embodiment 2 Preparation of crude product orotic acid

[0026] Put 5.0mol sodium hydroxide or its 30% aqueous solution into 1700ml water, put the intermediate product obtained in Example 1 in 10-30min, heat up to 50-110°C and react for 2-5h, after cooling, add hydrochloric acid to acidify, filter and wash , drying to obtain 110g of product. Yield: 70%.

Embodiment 3

[0027] The refining of embodiment 3 products

[0028] Heat 2000ml of water to 60-100°C, put the crude product into stirring, add 100ml of concentrated ammonia water, it can be completely dissolved, add 10g of activated carbon, boil for 10-30min, acidify with hydrochloric acid, cool to below 5°C and store for 5h, filter, wash and dry Obtain product 100g.

[0029] Product appearance: white crystal or powder, content: >99.5% (HPLC), pH: 2.5 (0.5g / 50ml water), heavy metal content: <20ppm, product ignition residue: 0.07%

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Abstract

The process of producing orotic acid includes the preparation of 5-bromo-2,6-dioxy-hexahydropyrimidine-4-carboxylic acid by using raw material including sodium bromide, chlorine and maleoyl carbamide, reaction of the obtained product with sodium hydroxide, acidification to obtain raw orotic acid and refining with concentrated ammonia water. The sodium bromide may be reused. The process has low cost, less corrosino of material to equipment and less environmental pollution and the prepared orotic acid may be used in production of cosmetics and medicine and research of biochemistry.

Description

technical field [0001] The invention belongs to a process for producing orotic acid. Background technique [0002] Orotic Acid (Orotic Acid) is named 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid (1,2,3,6-tetrahydro-2,6-dioxo-4 -pyrimidine-carboxylic acid). Molecular formula: C 5 h 4 N 2 o 4 [Angew.Chem.Int.Ed.7.][U.S.P., 2937157(1960)][U.S.P., 3086917(1963)], structural formula: . Orotic acid containing one molecule of water of crystallization (C5H 4 N 2 o 4 ·H 2 O) [C.A.N 50887-69-9] is a white needle-like crystal. Melting point 345-346°C (decomposition), 0.18g can be dissolved in 100ml water, 13g can be dissolved in 100ml boiling water, slightly soluble in organic solvents, insoluble in ether, odorless, sour taste. Orotic acid is known as a new member of the vitamin family VB 13 [Beil.25 253], orotic acid and its derivatives are widely used in medicine [Ger DD134870 28 Mar 1979 5pp][Parmazie34(5-6)390-10(German)1979][Actc.Chem.Scard 91955251 ][Bi...

Claims

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Application Information

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IPC IPC(8): C07D239/557
Inventor 杜恒邓敏智
Owner SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
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