Pre-formed gel sheet

A pre-forming and gel technology, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, sheet-like delivery, etc., can solve problems such as not pointing out and not describing gel sheeting devices, and achieve The effect of good mechanical properties

Inactive Publication Date: 2002-09-04
THE PROCTER & GAMBNE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Although the aforementioned patches or dressings in the cosmetic and pharmaceutical fields improve the desired physical and application properties, these documents do not describe aqueous self-supporting preformed sheets containing a mixture of at least two water-soluble polymeric gel formers. Gel sheet devices, wherein the device has not only a desired amount of syneresis, but also a desired strength and flexibility
Also, it is not stated that all three parameters are essential to obtain the desired application properties of a preformed gel sheet device

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0137] The invention is illustrated by the following examples.

[0138] Element

E.G.1

%(weight)

E.G.2

%(weight)

E.G.3

%(weight)

E.G.4

%(weight)

E.G.5

%(weight)

E.G.6

%(weight)

agar

0.6

0.4

-

-

0.6

0.4

Agarose

0.3

0.4

0.75

0.8

-

-

κ-Carrageenan

-

-

-

-

0.3

-

locust bean gum

0.1

-

-

-

-

-

Konjac Flour Mannan

0.2

-

0.1

-

0.3

0.3

xanthan gum

0.1

-

-

-

-

0.1

Kelgum TM1

-

0.3

0.3

0.3

-

-

polyvinylpyrrolidone

-

2.0

-

-

-

-

Glycerin

15.0

25.0

20.0

...

Embodiment 7-14

[0147] Examples 7-14 are comparative examples of gel patches described in the literature, and the gels were prepared as described in Examples 1-6 herein. The amount of exudate released, the percentage of compression at break and the force required for gel break of the gel composition in each example were measured, and the results are listed in the table below.

[0148] Element

[0149] 1. Kelgum TM is a 1:1 mixture of xanthan gum and locust bean gum purchased from Kelco (San Diego, CA, USA).

Embodiment 7

[0150] 2. Orgasol 2002D 2 Nylon-12 powder available from ELF Atochem, Paris, France. Example 7: WO 90 / 14110, Example 2 - Calcium alginate free. Example 8: WO 90 / 14110, Example 3 - Calcium alginate free.

[0151] GB 1,341,999, Example 1 - No silver nitrate. Example 9: JP 920649, Example 1. Example 10: EP-A-803245, gels based on this literature report. Example 11: GB 1,341,999, Example 2 - No silver nitrate. Example 12: EP-A-161681, Example 1. Example 13: EP-A-161681, gels based on the teaching that polysaccharide gums may contain combinations of carrageenan and galactomannan. Example 14: US-A-4,661,475, Example 3.

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PUM

PropertyMeasurementUnit
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Abstract

A preformed sheet device comprising: (a) less than 10% of a polysaccharide mixture consisting of: (i) red algae polysaccharide; (ii) mannose-containing polysaccharide selected from the group consisting of Mannan, glucomannan, and derivatives or mixtures thereof, and; (iii) fermented polysaccharides, or derivatives thereof; and (b) from about 30% to about 99.5% water; wherein the device contained The total amount of polysaccharides is less than 10%. The preformed sheet device of the present invention is suitable for topical application and exhibits a desired amount of syneresis and / or improved mechanical properties such as strength and elasticity, and exhibits excellent moisturizing, hydrating and cooling effects Beneficial effect. In addition, the device of the present invention is easy to handle when applied, has permeability, and can conform to the contour of the applied surface.

Description

[0001] the field [0002] The present invention relates to new preformed gel sheet devices. Specifically, the present invention relates to a self-adhesive, pre-formed gel sheet device that is a patch or mask, comprising from about 30% to about 99.5% water and a mixture of at least two water-insoluble polymeric gel formers for use in Delivers active ingredients to skin, hair and nails. The devices are suitable for topical application and exhibit desirable amounts of syneresis and improved mechanical properties such as strength and flexibility, and exhibit excellent moisturizing and hydration benefits. Furthermore, the devices of the present invention are unobtrusive and conform to the contours of the application surface. These desired properties are achieved through selection of the chemical composition and rheological properties of the preformed gel sheet device, in particular the relationship between exudate release, breaking force and percent compressio...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K9/70A61K8/04A61K8/72A61K8/73A61K45/00A61K47/36A61Q3/02A61Q5/00A61Q19/00
CPCA61K8/0208A61K8/0212A61K8/042A61K8/73A61K2800/594A61Q19/00A61K8/02
Inventor G·E·德克纳D·M·詹金斯K·E·凯特
Owner THE PROCTER & GAMBNE CO
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