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Antibiotics-polymer composition

A technology of antibiotics and complexes, applied in the direction of antibacterial drugs, active ingredients of carbohydrates, drug combinations, etc., can solve problems such as invasion of the body and infection

Inactive Publication Date: 2002-10-30
HERAEUS KULZER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the problem here is that microorganisms will enter the body through the plastic hose of the catheter and urinary catheter, causing local infection, and then continue to invade the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A solution was prepared consisting of 1.5 g poly(methyl methacrylate), 120 mg polyethylene glycol 600 and 5 ml acetone. 300 mg of finely powdered gentamicin-penta-hexadecylsulfonate and 300 mg of gentamicin sulfate were suspended in the solution. The suspension was poured onto a glass plate. The acetone was allowed to evaporate. At the same time, a translucent elastic film is produced, which can be peeled off from the glass plate.

Embodiment 2

[0042] A solution was prepared consisting of 1.5 g poly(methyl methacrylate), 120 mg polyethylene glycol 600 and 5 ml acetone. 300 mg of finely powdered gentamicin-penta-lauryl sulfate and 300 mg of gentamicin sulfate were suspended in the solution. A length of 3 cm long polyvinyl chloride hose (diameter 4 mm) is immersed in the suspension. Next, the coated polyvinyl chloride hose was allowed to dry at room temperature. A highly adherent elastic coating is obtained on PVC hoses.

Embodiment 3

[0044] In a melt (150°C) composed of 2g methacrylic acid-methyl acrylate copolymer and 200mg polyethylene glycol 600, put 200mg fine powdered gentamicin-penta-dodecylsulfate salt, and distribute it evenly. After the molten liquid is cooled, a milky white opaque solid compound is obtained.

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PUM

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Abstract

The present invention relates to an antibiotic-polymer complex that ensures continuous release of antibiotics for several days under physiological conditions and can be used in human and veterinary medicine. The antibiotic-polymer composite of the present invention is characterized in that it contains one or more hydrophobic polymers selected from the group consisting of polymethacrylates, polyacrylates, methacrylate-acrylate copolymers and a Or in a homogeneous mixture of polymers composed of hydrophilic polymers such as polyethers, one or more substances selected from the group consisting of aminoglycoside antibiotics, lincosamide antibiotics, tetracycline antibiotics, and quinolone antibiotics are suspended in water. A poorly soluble antibiotic, a water-soluble antibiotic selected from aminoglycoside antibiotics, lincosamide antibiotics, β-lactam antibiotics and tetracycline antibiotics as needed, and an organic auxiliary as needed material and causing the suspension to form a composite.

Description

technical field [0001] The present invention relates to an antibiotic-polymer compound which can guarantee the continuous release of antibiotics for several days under physiological conditions and can be used in human medicine and veterinary medicine. Background technique [0002] In both human and veterinary medicine, plastic medical products in the form of drainage tubes, urinary catheters, membranes and gauzes are used as temporary or permanent implants for secretion aspiration, irrigation, dressing and fixation. But the problem here is that microorganisms can enter the body especially through the plastic hose of the catheter and urinary catheter, thereby causing local infection, and then continue to invade the body. Similar problems arise when using clips in vitro. Microorganisms can then enter the body along the pin connection in the same way. For dental implants, the problem of infection on the implant surface is also an indisputable fact. Therefore, it is necessary...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61K9/00A61K9/70A61K31/00A61K31/65A61K31/70A61K31/7036A61K31/726A61K47/10A61K47/32A61K47/48A61L24/00A61L27/00A61L27/34A61L27/44A61L27/54A61L29/00A61L29/08A61L29/12A61L29/16A61L31/10A61L31/16A61P31/00
CPCA61K9/0019A61K9/0024A61K31/00A61K31/7036A61K47/10A61K47/32A61L27/34A61L27/54A61L29/085A61L29/16A61L31/10A61L31/16A61L2300/406A61L2300/45A61L2300/602A61L2300/606A61P31/00A61P31/04C08L33/04
Inventor S·福哥特M·斯纳波劳KL-D·科恩
Owner HERAEUS KULZER
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