Recombinant expression vector expressing human pancreatic tissue kallikrein gene and prepn of human pancreatic tissue kallikrein
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN PEOPLES HOSPITAL
- Publication Date
- 2002-12-11
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to a recombinant expression carrier carrying human pancreatic kallikrein gene, in particular to a recombinant expression carrier carrying human pancreatic tissue kallikrein mature protein gene.
[0002] The present invention also relates to host cells transformed by the recombinant expression vector.
[0003] The invention also relates to a method for preparing recombinant kallikrein by applying genetic engineering technology. Background technique
[0004] Human kallikreins fall into two major classes, plasma kallikreins and tissue kallikreins. Tissue kallikrein is a group of compounds with similar properties, which can be synthesized by liver, pancreas, cranial nerve, etc. The protein encoded by the tissue kallikrein gene is first expressed to generate a precursor intact protein, which becomes a biologically active mature protein after cleavage and processing by protease in vivo. The tissue kallikrein gene encodes tissue kalli...