High-tension condensed ring nicotine analogue, preparation process and use thereof

A technology for nicotine and analogues, which is applied in the field of ternary condensed ring nicotine analogues, can solve problems such as limiting medicinal value, and achieve the effects of simple synthesis methods, high yields, and good water solubility
CN1385429AInactive Publication Date: 2002-12-18SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
Publication Date
2002-12-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a ternary fused ring nicotine analogues and its intermediate product. Said invention provides its molecular formula, and said compound is high in chemical stability, good in water soluble property, and can be used for preparing the medicines for curing the diseases (such as senile dementia, etc.) due to nerve degeneration and disturbance.
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Description

technical field

[0001] The invention relates to a high-tension three-membered fused-ring nicotine analogue (1), which is formed by linking the C4 position of the pyridine ring and the C3' position of the pyrrole ring in the nicotine structural unit (3) through a certain carbon chain. technical background

[0002] In the process of developing drugs for treating neurodegenerative diseases, it was found that the nicotine acetylcholine receptor (nAChR) in neurons is an important class of target molecules [Neuropharmacology 1995, 34, 563]. Many studies have confirmed that the natural alkaloid nicotine has a certain effect on the treatment and alleviation of Parkinson's disease, Alzheimer's disease and Tourette's disease, but its inherent toxic and side effects on the cardiovascular and digestive system greatly limit its medicinal value[ Chem. Eng. News 2000, 78, 23-26]. By systematically studying and summarizing the structure-activity relationship of nAChR ligands [J.Med.Chem....

Claims

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