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Biological fluid dressing chitosan membrane and its preparing process

A biofluid, chitosan technology, applied in dressings, viscous dressings, etc., can solve the problems of drug resistance and single function, and achieve the effect of accelerating healing, high oxygen permeability, and shortening healing time.

Inactive Publication Date: 2003-02-12
ZHEJIANG ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional external wound medicines are mostly chemical antibiotic ointments, which have a single function, and long-term use can easily lead to drug resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: take by weighing 425 grams (final concentration is 1.42%) of medium viscosity chitosan through 80 ℃ of drying and put in the stirrer, add 25 kilograms of filtered waters, stir well, stirring speed is 65-296r / min, while Slowly add 225ml of concentrated acetic acid while stirring, the pH value is 3, and the process takes about 2-3 hours. % sodium bicarbonate solution 3000ml slowly adjust the pH value of the chitosan solution to 6.2, the process takes about 2-3 hours, filter, remove the bubbles overnight, which is a semi-finished product. The next day, measure the pH value and viscosity of the chitosan solution again. The pH value is 6.2. Use a rotary viscometer (25°C) to measure the viscosity as 1000mpa.s. Pack it in an aluminum tube and carry out a sterility test. If it is qualified, it is the finished product. .

Embodiment 2

[0017] Embodiment 2: take by weighing 492 grams (final concentration is 1.6%) of medium-viscosity chitosan through 80 ℃ of drying and put in the stirrer, add 25 kilograms of filtered waters, stir well, stirring speed is 65-296r / min, while Slowly add 225ml of concentrated acetic acid while stirring. The pH value is 3. The process takes about 2-3 hours. % sodium bicarbonate solution 4000ml slowly adjust the pH value of the chitosan solution to 6.0, the process takes about 2-3 hours, filter, and remove the bubbles overnight, which is a semi-finished product. Measure the pH value and viscosity of the chitosan solution the next day, the pH value is 6.0, with a rotary viscometer (25°C), the measured viscosity is 1900mpa.s, packed in aluminum tubes, and the sterility test is carried out, and it is qualified finished product.

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PUM

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Abstract

A biodressing film for treating skin wound, burn and skin ulcer is prepared from chitosan as main raw material through acidolysis, adding gelatin and glycerin, neutralizing with dicarbonate, and filtering. Its advantages are high biocompatibility, netural antibacterial activity, and no poison and irritation.

Description

technical field [0001] The invention is a novel biological dressing, which is a chitosan biological fluid dressing film mainly used for skin wounds, burns and body surface ulcers and a preparation method thereof. Background technique [0002] Chitosan, the main component of biofluid dressing films, is a derivative of chitin, one of the most abundant organic resources on earth, and its chemical name is β-(1-4)-2-amino-2-deoxy-D-glucose Polysaccharides are currently processed mainly from the shells of crabs and shrimps in the ocean. In recent years, domestic and foreign countries have attached great importance to the development and utilization of chitin and its derivatives, and found that they have broad application prospects in the field of medicine. Most of the traditional external wound medicines are chemical antibiotic ointments, which have a single function, and long-term use can easily lead to drug resistance. Therefore, it is the development...

Claims

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Application Information

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IPC IPC(8): A61F13/02A61K47/36
Inventor 蒋玉燕毕忆群蒋建国
Owner ZHEJIANG ACAD OF MEDICAL SCI
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