Nimodipine lipid nano particle compositions, and its prepn. method

Abstract

The present invention relates to a nimodipine lipid nano granular composition and its preparation method. It can be made into injection, its composition includes 0.002-0.2% of nimodipine, 0.02-10% ofphospholipid and 0-2% of Poloxamer. Its preparation method includes the following steps: dissolving the above-mentioned materials in ethyl alcohol, adding injection water, making hydration for 1-2 hr. to obtain nimodipine lipid granular solution, high-pressure homogenizing for 10 min. under the condition of nitrogen gas flow, filtering with 0.2 micrometer micropore filtering membrane, adding injection water, filling, sealing, sterilizing so as to obtain the invented product.

Description

Technical field:

[0001] The invention relates to the technical field of medicine, in particular to a nimodipine lipid nanoparticle composition and a preparation method thereof. Background technique:

[0002] Nimodipine is a calcium channel blocker, which can dilate blood vessels and prevent cerebral ischemic damage. It is an ideal drug for patients with cerebrovascular diseases. No obvious adverse reactions (Li Zhaoren Nimodipine New Drug and Clinical 1987, 6(2): 12-124). It has the following characteristics: (1) Selective expansion of cerebral blood vessels: (2) Increase cerebral blood flow without 'blood stealing' phenomenon: (3) Increase cerebral blood circulation without increasing cerebral metabolism: (4) Anti-platelet aggregation. It is clinically used to treat subarachnoid hemorrhage, migraine, stroke, cerebrovascular insufficiency, sudden deafness, vestibular nystagmus, etc. In view of the above-mentioned characteristics, there are many dosage forms of nimodipine d...