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Process for preparing astraglus base total saponin

A technology of astragalus total saponins and astragalus, applied in the field of medicine, can solve problems such as complicated operation steps, high production cost, and low yield, and achieve the effects of simple and standardized process, low production cost, and high yield

Inactive Publication Date: 2003-06-25
SHANGHAI JINGFENG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation methods of astragaloside mainly include water extraction and alcohol precipitation method, and the alcohol solution is used to separate saponins. With this method, astragaloside is greatly lost, the yield is low, and the production cost is high; it can also be extracted with alcohol organic solvents. , after concentrating, passing through a macroporous adsorption resin column, and gradient elution with water and alcohol solutions of different concentrations, using this method, the operation steps are complicated, the impurity content is high, the color of astragaloside is deep, and the purity is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] After 10 kg of Radix Astragali root is pulverized, it is extracted three times under reflux with water in a heating reflux extraction tank. The combined extracts were added to the AB-8 macroporous adsorption resin column, and the sugars were eluted with 100 liters of deionized distilled water, and then eluted with 50 liters of 0.1% sodium hydroxide aqueous solution, followed by 50 liters of 20% sodium hydroxide Alcohol elution for decolorization. The astragaloside was then eluted with 25 liters of 75% alcohol, the eluate was concentrated to a small volume, and centrifuged to obtain 5.435 g of the precipitate A part. Add alcohol to the mother liquor until the alcohol concentration is 70%, centrifuge, separate the supernatant, concentrate and dry to obtain part B. After part A and part B were mixed, 8.637 grams of total astragalus saponins were obtained, with a yield of 0.08637%.

Embodiment 2

[0017] After 10 kg of Radix Astragali root is pulverized, it is extracted three times under reflux with water in a heating reflux extraction tank. The combined extracts were added to the D101 macroporous adsorption resin column, and the sugars were eluted with 90 liters of deionized distilled water, then eluted with 50 liters of 0.1% potassium hydroxide aqueous solution, and then washed with 50 liters of 20% alcohol. Decolorize. The astragaloside was then eluted with 25 liters of 80% alcohol, the eluate was concentrated to a small volume, and centrifuged to obtain 5.754 g of the precipitate A part. Add alcohol to the mother liquor until the alcohol concentration is 70%, centrifuge, separate the supernatant, concentrate and dry to obtain part B, and mix part A and part B to obtain 9.036 g of total astragalosides, with a yield of 0.09036%.

Embodiment 3

[0019] After crushing 10 kg of Radix Astragali root, reflux extraction with water twice in a heating reflux extraction tank. The combined extracts were added to the ZTC-1 macroporous adsorption resin column, the sugars were eluted with 110 liters of deionized distilled water, and then eluted with 50 liters of 0.1% sodium hydroxide aqueous solution, followed by 50 liters of 20% sodium hydroxide Alcohol elution for decolorization. The astragaloside was then eluted with 25 liters of 80% alcohol, the eluate was concentrated to a small volume, and centrifuged to obtain 5.872 g of the precipitate A part. Add alcohol to the mother liquor until the alcohol concentration is 80%, centrifuge, separate the supernatant, concentrate and dry to obtain part B, and mix part A and part B to obtain 9.263 g of total astragalosides, with a yield of 0.09263%.

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Abstract

The present invention relates to the preparation process of general astralus saponin. Astragalus root material is twice hydrothermal reflux extracted; and the extracted liquid is filtered, desugarized and decolored in macroporous adsorption resin, separated and purified to obtain general astraslus saponin mixture with general astragalus saponin content of 80-98% and astraslus saponin A content of 50-80%.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a method for preparing astragalus total saponins from the traditional Chinese medicine astragalus. Background technique [0002] Radix Astragali (Radix Astragali) is the dry root of Astragalus membranaceus (Fisch) Bge.Var.mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch) Bge. of the leguminous plant Astragalus membranaceus (Fisch) Bge. Mild in nature, traditional medicine believes that it has the effects of invigorating qi and strengthening the surface, diuretic and detoxification, astringing sores and promoting granulation, and has a long history of medicinal use. Modern studies have shown that astragalus has the effects of enhancing immunity, metabolism, lowering blood pressure and diuresis, among which astragalosides, especially astragaloside IV, are its main physiologically active components. At present, the preparation methods of astragaloside mainly...

Claims

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Application Information

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IPC IPC(8): C07H17/07
Inventor 李慧梁张卫东邹豪
Owner SHANGHAI JINGFENG PHARMA
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