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Fermentation production technology for olry bacterial powder containing gama-linolenic acid

A production process and production process technology, applied in the field of biological drugs, can solve problems such as irreplaceable, unable to meet domestic and foreign market demand, raw material source restrictions, etc., to achieve better effects, prevention of virus invasion, and stable product quality.

Inactive Publication Date: 2003-08-06
向芙戊 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no drug can replace or exceed the effect of gamma-linolenic acid combined with traditional Chinese medicine on the human body
[0004] At present, the gamma-linolenic acid produced at home and abroad is mainly derived from evening primrose, but due to the limited source of raw materials, it is far from meeting the growing domestic and foreign market demand

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The gamma-linolenic acid bacteria present in the oil of some spore plants and seed plants are used as culture and fermentation strains:

[0044] The strains are screened under the conditions in the incubator;——

[0045] The slant culture of the bacteria is to shake at 25°C for 5 days;——

[0046] Fermentation in a primary fermentation tank at 25°C for 3 days;——

[0047] Fermentation in the secondary fermentation tank at 25°C for 5 days;——

[0048] Fermentation in a three-stage fermenter at 25°C for 5 days;——

[0049] Fermentation for 7 days at 25°C in a four-stage fermenter;——

[0050] Then filter the bacteria and dehydrate the bacteria, and then shake and dry at 50°C;——

[0051] Finally, 120-mesh crushing and sieving, aseptic vacuum packaging of the product and storage of the product.

[0052] The slant culture refers to the inoculation of the enlarged cultured strains in the liquid culture solution, and vibration culture at 25° C. for 5 days on a shaker at 150 rpm...

Embodiment 2

[0065] The gamma-linolenic acid bacteria present in the oil of some spore plants and seed plants are used as culture and fermentation strains:

[0066] The strains are screened under the conditions in the incubator;——

[0067] The slant culture of the bacteria is shaken at 28°C for 3 days;——

[0068] Fermentation in a primary fermentation tank at 28°C for 3 days;——

[0069] Fermentation in a secondary fermenter at 28°C for 3 days;——

[0070] Fermentation in a three-stage fermenter at 28°C for 3 days;——

[0071] Fermentation at 28°C for 6 days in a four-stage fermenter;——

[0072] Then filter the bacteria and dehydrate the bacteria, and then shake and dry at 60°C;——

[0073] Finally, 160-mesh crushing and sieving, aseptic vacuum packaging of the product and storage of the product.

[0074] The slant culture refers to the inoculation of the enlarged cultured strains in the liquid culture solution, and vibration culture at 28° C. for 3 days on a shaker at 150 rpm.

[0075] ...

Embodiment 3

[0087] The gamma-linolenic acid bacteria present in the oil of some spore plants and seed plants are used as culture and fermentation strains:

[0088] The strains are screened under the conditions in the incubator;——

[0089] The slant culture of the strain is to shake at 30°C for 2 days;——

[0090] Fermentation in the primary fermentation tank at 30°C for 1 day;——

[0091] Fermentation in the secondary fermenter at 29°C for 2 days;——

[0092] Ferment for 2 days at 30°C in a three-stage fermenter;——

[0093] Fermentation in four-stage fermenter at 30°C for 5 days;——

[0094] Then filter the bacteria and dehydrate the bacteria, and shake and dry at 70°C;——

[0095] Finally, 200-mesh crushing and sieving, aseptic vacuum packaging of the product and storage of the product.

[0096] The slant culture refers to the inoculation of the enlarged cultured strains in the liquid culture solution, and vibration culture at 30° C. for 2 days on a shaker at 150 rpm.

[0097] Described...

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Abstract

The present invention relates to a gamma-linolenic acid fermentation production process for producing gamma-linolenic acid. The technological process includes the following steps: screening gamma-linolenic acid being in spore plant and plant seed oil as inoculum for culture and fermentation, slant culture of inoculum is vibration culture for 2-5 days at 25-30 deg.C, in first stage fermentation tank making fermentation for 1-3 days at 25-30 deg.C, in second stage fermentation tank making fermentation for 2-5 days at 25-29 deg.C, in third stage fermentation tank making fermentation for 2-5 daysat 25-30 deg.C, in fourth stage fermentation tank making fermentation for 5-7 days at 25-30 deg.c, then filtering thallus anjd dehydrating, vibration drying at 50-70 deg.C, finally pulverizing and sieving with 120-200 meshes.

Description

technical field [0001] The invention relates to a biomedicine capable of treating and preventing various diseases such as AIDS, diabetes, hypertension, cardiovascular disease, endocrine disorders, etc., especially a fermentation production process of dry bacterial powder containing gamma-linolenic acid. technical background [0002] γ-linolenic acid, scientific name 6, 9, 12, octadecatrienoic acid, is all-cis, non-conjugated three-dimensional structure, molecular formula is C18H30O2, and its properties are colorless or light yellow oily liquid, due to its high degree of unsaturation It is unstable in the air, especially under high temperature conditions, it is prone to oxidation reaction, and it is prone to double bond position and configuration isomerization reaction under alkaline conditions to form conjugated polyene acid. [0003] As an essential fatty acid for the human body, γ-linolenic acid is a structural material for the biofilm of various tissues in the human body,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K38/44A61P9/10A61P9/12A61P31/18C12N9/02C12P1/04C12P7/40C12P21/00
Inventor 王玉兰向芙戊
Owner 向芙戊
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