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Steroid saponin from sealwort as Chinese medicine material and its medicinal use and prepn process

A technology of steroidal saponins and Polygonatum, which is applied in the field of steroidal saponins in Polygonatum Polygonatum and its medicinal use and preparation, can solve the problems of few researches on chemical components, improve learning and memory impairment, prolong survival time, and suppress blood sugar levels Effect

Inactive Publication Date: 2003-09-10
SHENYANG PHARMA UNIVERSITY
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  • Abstract
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  • Claims
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Problems solved by technology

There are few studies on the chemical constituents of the traditional Chinese medicine Polygonatum sibiricum, only reports on alkaloids and polysaccharides, but no research on its steroidal saponins

Method used

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  • Steroid saponin from sealwort as Chinese medicine material and its medicinal use and prepn process

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Embodiment

[0023] Rhizome of Rhizoma Polygonatum (30kg) was pulverized, extracted with water 3 times, 2 hours each time, extracted and concentrated to obtain water extract, then diluted with water, extracted with chloroform and n-butanol respectively to obtain parts with different polarities. Treat the n-butanol part with macroporous resin column chromatography to obtain the total steroidal saponins of Polygonatum. Polygonatum total steroidal saponins were obtained by silica gel column chromatography, recrystallization and Rp18-HPLC and other methods to obtain 11 monomeric compounds.

[0024] Identification of some compounds:

[0025] Compound 2: Huangjinoside A (huangjinoside A), white powder, mp250-252°C (MeOH).

[0026] Compound 3: Huangjinoside B (huangjinoside B), white powder, mp256-259°C (MeOH).

[0027] Compound 4: huangjinoside C (huangjinoside C), white powder, mp291-293°C (MeOH).

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PUM

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Abstract

The present invention relates to steriod saponin from sealwort as Chinese medicine material and its medical use and preparation process. It has the effects of improving cerebral function and lowering blood sugar level. It is prepared with sealwort root powder and through water extraction, concentration, chloroform extraction, macroporous resin adsorption, dilute alcohol washing to eliminate impurity, alcohol elution to obtain alcohol solution, recovering solvent to obtain steriod saponin, silica gel chromatography to separate, re-crystallization, and HPLC chromatography to obtain triterpenoid saponin monomer. The present invention is suitable for industrial production and has the functions of improving learning and memory capacity of early stage senile dementia.

Description

Technical field: [0001] The invention relates to the preparation of triterpene saponins in the stems and leaves of American ginseng in the technical field of medicine, in particular it is a steroidal saponin in the traditional Chinese medicine Rhizoma Polygonatum and its medical application and preparation method. Background technique: [0002] Polygonatum sibiricum, a traditional Chinese medicine, is the rhizome of Polygonatum sibiricum, a perennial herb of the genus Polygonatum in the Liliaceae family. It is distributed all over the country, mainly in the three northeastern provinces, Inner Mongolia, Hebei, Shaanxi, Shandong and other places. Chinese Pharmacopoeia (1995 Edition) contains three kinds of Polygonatum original plants, namely: Polygonatum sibiricum, Polygonatum cyrtonema and Polygonatum kingianum. It was first recorded in "Bielu of Famous Doctors" and listed as top grade. It is flat in nature, sweet in taste, non-toxic, and belongs to the spleen, lung, and kidn...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10A61P25/28C07J71/00
Inventor 李铣孙隆儒王金辉
Owner SHENYANG PHARMA UNIVERSITY
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