Antithrombotic agents
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SMITHKLINE BECKMAN CORP
- Publication Date
- 2004-06-02
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
field of invention
[0001] The present invention relates to monoclonal antibodies (mAbs) that bind to human coagulation factors or cofactors and their use as inhibitors of thrombosis. Background of the invention
[0002] Under normal conditions, damage to the vascular endothelial cells of the vascular intimal membrane, regardless of the size of the damage, will trigger a hemostatic response through a series of events commonly referred to as the coagulation "cascade". This cascade reaction culminates in the conversion of soluble fibrinogen to insoluble fibrin, which together with platelets forms a local blood clot or thrombus that prevents extravasation of blood components. Wound healing then occurs as the clot dissolves and vascular integrity is repaired and blood flow restored.
[0003] The events that occur between injury and clot formation are finely regulated and linked by a series of responses. Briefly, large amounts of plasma coagulation proteins and cofactors circula...