Medicine for treating climacteric syndrome

A syndrome and drug technology, applied in the directions of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems of not being used as a treatment for menopausal syndrome, and achieve clinically moderated effects, less side effects, and less irritating effects. Effect

Inactive Publication Date: 2004-07-07
庞飞 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, it has not been used as a drug for the treatment of menopausal syndrome, especially senile and atrophic vaginitis

Method used

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  • Medicine for treating climacteric syndrome
  • Medicine for treating climacteric syndrome
  • Medicine for treating climacteric syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Process 25 grams of Prasterone Sulfate Sodium (medicinal Prosterosterone Sulfate Sodium, conforming to the 2000 edition of the Chinese Pharmacopoeia, produced by Jiangsu Yangzhou Pharmaceutical Factory) into powder by jet milling and other methods so that the particle size is 20 to 100 microns. Powdered prasterone sulfate sodium and 39 grams of pregelatinized starch (pregelatinized starch, medicinal, Chinese Pharmacopoeia 2000 edition, produced by Huzhou Food and Chemical United Company) and 16 grams of microcrystalline cellulose (microcrystalline cellulose, pharmaceutical Use, Chinese Pharmacopoeia 2000 edition, produced by Shanghai Zhaotun Pharmaceutical Factory) and mix uniformly, add a concentration of 10% (percentage by weight) of starch slurry in an appropriate amount (it is advisable to make the resulting mixture suitable for granulation by conventional methods), mix uniformly , made into a soft material, granulated with a 20-mesh nylon sieve, dried at 50°C for 2 ...

Embodiment 2

[0038] According to the method of Example 1, commercially available Prasterone Sulfate Sodium with common particle size (medicinal Prasterone Sulfate Sodium, conforming to the Chinese Pharmacopoeia 2000 edition, produced by Jiangsu Yangzhou Pharmaceutical Factory) was mixed with other components to prepare pharmaceutical preparation B of the present invention.

Embodiment 3

[0040] Investigate the fluidity of the granules of the preparation A obtained in Example 1, the degree of difficulty of tableting, and the disintegration and dissolution properties after tableting, and the results are listed in the following table. It can be seen from the data in the table that the granules of preparation A have good fluidity, the tablets are formed well, and the disintegration and dissolution rates all meet the requirements.

[0041] Table 1 Quality inspection results after tablet compression

[0042]

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Abstract

A medicine for treating the woman's climacteric syndrome, especially the senile atrophic vaginitis features that it contains prasterone sodium sulfate. Its advantages are high curative effect, low toxic by-effect, and no irritation to endometrium.

Description

technical field [0001] The invention relates to a medicine for treating climacteric syndrome, especially a medicine for treating women's senile and atrophic vaginitis. Background technique [0002] Women will enter menopause sooner or later around the age of 40. Women in this period will experience a series of menopausal syndromes, which may be mild or severe, which will bring them pain. At present, hormone replacement therapy (HRT) is often used at home and abroad to treat women's menopausal syndrome. Commonly used drugs for hormone replacement therapy at home and abroad include Beili, Livial and so on. Bemelil has certain potential side effects and has been discontinued in many countries. Livial has the effects of estrogen, androgen and progesterone. As a synthetic steroid-like substance, it has a greater stimulating effect on the endometrium. [0003] Usually, more than 30% of women suffer from atrophic vaginitis after menopause. This condition can also occur in pati...

Claims

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Application Information

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IPC IPC(8): A61K31/566A61P15/12
Inventor 杨维稼李建新
Owner 庞飞
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