Sterilization method of furacillin solutions

Abstract

The invention discloses a sterilization process for furacilin solution comprising the steps of, heating the prepared furacilin solution to above 60 deg. C through 60-100 deg. C or vapor or dry hot air, sustaining for 10-60 minutes, then placing for 6-48 hours, repeating the operation 1-5 times, finally storing it in sealed photophygous container.

Description

technical field [0001] The invention relates to a sterilization method of an externally used bacteriostatic drug preparation, in particular to a sterilization method of a nitrofurazone solution. Background technique [0002] The chemical name of nitrofurazone is 5-nitro-2-furyl semicarbazone, the English name is Furalilinum, and the molecular formula is C 6 h 6 o 4 N 4 , with a molecular weight of 198.15, is a synthetic nitrofuran topical disinfectant, which can interfere with the sugar metabolism process and oxidase system of bacteria to play a bacteriostatic or bactericidal role, and mainly interfere with the early stage of bacterial sugar metabolism, resulting in Bacterial metabolism disorder and death. As a synthetic antibacterial drug, nitrofurazone is generally not suitable for oral administration in clinical practice due to its irritating effect on the gastrointestinal tract. However, due to its broad antibacterial spectrum, it has resistanc...

AI Technical Summary

Problems solved by technology

The reason may be that the furan ring in the nitrofurazone solution is unstable and its nitro structure has strong oxidizing properties, making it unstable to light and heat, easy to oxidize, and easy to precipitate crystals.

And at present in the process of preparing nitrofurazone solution, most of them adopt the method of 115 ℃ hot-pressed steam sterilization for 30 minutes to sterilize, which is prone to local overheating, which further aggravates the instability and easy oxidation of nitrofurazone solution, and the color of nitrofurazone solution changes. Deep, the content of active ingredients has dropped significantly

Simultaneously the prepared nitrofurazone solution will also have the above-mentioned stability problems very quickly under the irradiation of natural light

Therefore, nitrofurazone solution is difficult to realize industrialized mass production and long-term storage, far from meeting the needs of clinical medication