Capsule of Chinese traditional medicine for treating thrombus

A traditional Chinese medicine capsule and vascular embolization technology, which is applied in the field of pharmaceutical compositions for treating vascular embolism, can solve the problems of affecting the curative effect of the drug, low content of active ingredients, etc., and achieve the effects of being beneficial to the drug efficacy, avoiding side effects and delaying the formation of thrombosis

Inactive Publication Date: 2004-10-27
SHANXI MAIDI PHARMA
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AI Technical Summary

Problems solved by technology

In some literatures, earthworm extracts or astragalus extracts are also used, but the contents of fibrinolytic enzymes and earthworms in the earthworm ext

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0027] The traditional Chinese medicine capsule preparation for treating vascular embolism of the invention is prepared from earthworm extract and astragalus extract.

[0028] The preparation process of extracting plasmin and dilongin from earthworm:

[0029] Clean the fresh earthworm, make it into a homogenate with a tissue homogenizer, and then carry out centrifugation. After the earthworm homogenization, the speed of the first centrifugal treatment is 7000-9000 rpm, and the treatment time is 30 minutes; the supernatant is collected for acid denaturation, and sodium acetate solution is added to make the concentration of sodium acetate in the supernatant When it reaches 30-60mol / L, put it aside for 4-8 hours and then carry out the second centrifugation treatment, the rotation speed is 10000-15000 rpm, the treatment time is 15 minutes, and the supernatant is collected after centrifugation.

[0030] Pass the collected supernatant through a medium-pressure chromatographic colum...

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Abstract

A Chinese medicine in the form of capsules for treating vascular thrombus and decreasing blood viscosity is prepared from fresh earthworm and astragalus root through extracting their active components and proportionally mixing.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating vascular embolism, in particular to a traditional Chinese medicine capsule preparation capable of removing cerebral thrombus and coronary artery thrombus. Background technique [0002] At present, there are many literature reports on the treatment of vascular embolism with traditional Chinese medicine, involving a variety of prescriptions, dosage forms and different curative effects. Among them, studies on astragalus and earthworm alone or involving astragalus and earthworm in the prescription have also been reported, but in the preparation process, the method of decocting and water extraction is mostly used, and the technology is backward. In particular, when Earthworm is processed and decocted, the active substances of proteins and enzymes in its tissue have been destroyed, resulting in poor curative effect of the medicine. [0003] Modern studies have proved that the active ingredie...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/19A61K9/48A61K31/7048A61K35/62A61P7/02A61P9/10
Inventor 解军徐钧聂继盛于保锋胥显民陈显久黄登宇董华慧谭杏丽
Owner SHANXI MAIDI PHARMA
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