Compound abiduoer preparation with wide spectrum in resisting influenza viral

An Arbidol and anti-viral technology, applied in the field of anti-viral drug production, can solve the problems of antipyretic, analgesic, anti-inflammatory and anti-allergic clinical trials without response

Inactive Publication Date: 2004-11-17
吉林省吴太感康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The original drug Arbidol hydrochloride (6-bromo-5-hydroxy-4-dimethylaminomethyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester hydrochloride monohydrate, Arbidol hydrochloride) is A new type of antiviral drug from Russia, which has a certain inhibitory effect on respiratory viruses, but has no response to antipyretic, analgesic, anti-inflammatory and anti-allergic clinical trials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take Arbidol 10kg, paracetamol 25kg, loratadine 0.2kg raw material and auxiliary material powdered sugar 1.9kg, starch 3.6kg, starch starch 1.4kg, magnesium stearate 0.5kg for the preparation of 100,000 tablets of medicine .

[0019] The raw materials and auxiliary materials were pulverized in a pulverizer for 30 minutes, and then sieved through a 100-mesh sieve for later use. Weigh the raw and auxiliary materials respectively, mix them evenly, and pass through an 80-mesh sieve to make them fully mixed.

[0020] Operating process:

[0021] Put Arbidol, acetaminophen, loratadine, powdered sugar, and dry starch into the pot material of the wet mixing granulator, dry mix evenly, add starch slurry to make wet granules.

[0022] Starch slurry preparation method: put the boiled starch in the batch into the boiled slurry tank, add pure water to make it 15% concentration, stir it to make it into a uniform suspension, then heat it to about 75°C for gelatinization, and deflate ...

Embodiment 2

[0038] One, the influence of embodiment 2 on mouse hot plate analgesic effect

[0039] Use the YLS-6A intelligent hot plate instrument to set the temperature at 55°C as a thermal stimulus, record the latency period of the mice licking their hind feet since they were put into the hot plate instrument as the pain threshold of the mouse, and measure the pain threshold of each mouse before administration. The pain threshold of the mice was used as the basic pain threshold, and those who were happy to jump were excluded, and those who were 5-30s were qualified, and 50 female mice qualified for the screening were divided into 5 groups, namely, the positive control group acetaminophen (250mg / kg); Embodiment 2 high, middle and low three dosage groups (355mg / kg, 118mg / kg, 71mg / kg); The pain threshold of mice, the results are shown in Table 1.

[0040] Table 1 The effect of Example 2 on the analgesic effect of the hot plate method in mice (X±S n=10)

[0041] Group Dose

[0042]...

Embodiment 3

[0218] Take Arbidol 10kg, paracetamol 25kg raw materials and auxiliary materials powdered sugar 1.9kg, starch 3.6kg, starch starch 1.4kg, magnesium stearate 0.5kg to prepare 100,000 tablets of medicine. Other items should meet the relevant requirements of the Pharmacopoeia of the People's Republic of China 2000 Edition tablet items.

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PUM

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Abstract

The invention provides a compound Arbidol hydrochloride wide spectrum antiviral influenza medicament, which is prepared from Arbidol hydrochloride, acetaminopher and chlorpheniramine or Loratadine. The compound can be prepared into oral medication through the conventional preparation process.

Description

Technical field: [0001] The invention relates to a novel broad-spectrum antiviral medicine, specifically discloses a compound Arbidol broad-spectrum antiviral cold medicine, and belongs to the technical field of antiviral medicine production. Background technique: [0002] The original drug Arbidol hydrochloride (6-bromo-5-hydroxy-4-dimethylaminomethyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester hydrochloride monohydrate, Arbidol hydrochloride) is A new type of antiviral drug from Russia, which has a certain inhibitory effect on respiratory viruses, but has no response to antipyretic, analgesic, anti-inflammatory and anti-allergic clinical trials. Invention content: [0003] The invention provides a compound Arbidol broad-spectrum antiviral drug, which has a strong inhibitory effect on influenza A virus H1N1 subtype and respiratory syncytial virus, and also has a certain inhibitory effect on adenovirus type 3. It has antipyretic, analgesic, anti-inflammatory an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/405A61P31/12
Inventor 李欣
Owner 吉林省吴太感康药业有限公司
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