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Application of reducing glutathione in pharmacy

A glutathione and reduced technology, applied in the field of reduced glutathione, to achieve the effect of no toxic and side effects

Inactive Publication Date: 2004-11-17
NANJING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical epidemiological data show that the incidence of systemic inflammatory response syndrome (SIRS) accounts for 1 / 3 of hospitalized patients, and the fatality rate of systemic inflammatory response syndrome (SIRS) is 7%-26.5%. (MODS) has a mortality rate of more than 50% (BrunBC The epide miology of the systemic inflammatory response. Intens Care Med2000; 26 (Suppl1): S64; Lu Chongliang Systemic Inflammatory Response Syndrome Huaxia Medicine 2001; 14 (4): 254). There is a lack of effective drugs to resist systemic inflammatory response syndrome (SIRS) and inhibit the occurrence of multifunctional organ failure syndrome (MODS) in its later stage

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  • Application of reducing glutathione in pharmacy
  • Application of reducing glutathione in pharmacy
  • Application of reducing glutathione in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, to the observation of systemic inflammatory response syndrome (SIRS) rat fatality rate

[0029] (1) Principle: Up to 50% of systemic inflammatory response syndrome (SIRS) patients are caused by Gram-negative bacterial infection, and the bacterial cell wall outer membrane component lipopolysaccharide (Lipopolysaccharide, LPS) acts on myeloid and nonmyeloid The cells trigger the excessive release of various inflammatory mediators and the excessive activation of inflammatory cells, resulting in a cascade effect, which eventually leads to the imbalance of anti-inflammatory and pro-inflammatory in the body, triggering systemic inflammatory response syndrome (SIRS) (Jiang Jianxin, Chen Huisun, Diao Youfang, etc. After hemorrhagic shock The distribution of endogenous endotoxin in tissue circulation and its influence on organ function. (Medical Journal of the PLA, 1998, 23 (2): 131), and even cause multifunctional organ failure in the body, eventually leading to in...

Embodiment 2

[0038] Embodiment 2, to the mensuration of multiple physiological indexes of systemic inflammatory response syndrome (SIRS) rats

[0039] 1. Principle: In 1991, the joint meeting of the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) proposed indicators for systemic inflammatory response syndrome (SIRS) to be respiration, heart rate, body temperature and white blood cell count (Lu Chongliang. Systemic inflammation Reaction syndrome. Huaxia Medicine, 2001, 14(4): 254, Cai Zaitong, Lou Bincheng, Liu June. Observation of vital signs in patients with systemic inflammatory response syndrome, Chinese Journal of Nursing, 2001, 36(10): 751- 753.) In SIRS, an individual develops respiratory distress and failure, increased heart rate, increased or decreased body temperature, and increased or decreased white blood cell count. However, when MODS occurs, there will be a drop in body temperature and a decrease in the number of white blood cells, ...

Embodiment 3

[0099] After embodiment 3, LPS stimulates rats, the impact on the change of nitric oxide (NO) content in rat blood

[0100] 1. Principle: The increase of NO content is the result of systemic inflammatory response syndrome (SIRS). The role of NO in systemic inflammatory response is to lower blood pressure and generate oxygen free radicals such as ONOO. ONOO is the main substance of NO-induced cytotoxicity , excessive oxidative free radicals lead to cell necrosis, tissue damage and organ failure. In this experiment, the level of NO in blood of rats was measured after LPS stimulation for 15 hours.

[0101] 2. Experimental method:

[0102] (1) Instruments and materials: 721 spectrophotometer, cryogenic centrifuge, NO determination kit (built in Nanjing)

[0103] (2) Experimental method: the grouping of male SD rats is the same as above, the three groups of rats take blood at 15 hours, centrifuge at 3000rpm, take the supernatant, operate according to the steps specified in the NO...

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Abstract

The invention discloses a novel use of deacidized type glutathione (GSH) in the field of pharmacy, which can be applied for the treatment of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS), and has the effects of suppression of body temperature rapid decrease, lowering tachypnea and respiratory distress, intensifying leucocyte number, and alleviating heart rate quickening.

Description

1. Technical field [0001] The present invention relates to the novel use of reduced glutathione (GSH), especially relates to the application in pharmacy. 2. Background technology [0002] Reduced glutathione, i.e. r-glutamylcysteinylglycine, is a tripeptide that widely exists in animals and plants, and its structural formula is as follows: [0003] [0004] Reduced glutathione contains free sulfhydryl groups, has reductive and antioxidative effects, and has been widely used in the research and application of antiaging and antioxidative effects (Shen Tong, Wang Jingyan, etc. Biochemistry. Higher Education Press. 1990 , 12) [0005] The present invention discloses a new medicinal value of reduced glutathione as an inhibitory drug for systemic inflammatory response syndrome, which is useful for the treatment of systemic inflammatory response syndrome (SIRS) and its late multifunctional organ failure syndrome (MODS) Find effective medicines. [0006] Systemic Inflammatory ...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K38/06A61P29/00
Inventor 罗兰孙苏文张泓毛蓥荥余胡清殷志敏
Owner NANJING UNIV
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