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Dysmenorrhea treating solid medicine prepn and its prepn process

A technology for solid preparations and raw materials, which is used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of simple operation, easy storage, and convenient taking.

Inactive Publication Date: 2004-11-24
上海海虹实业(集团)巢湖今辰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to avoid the deficiencies in the above-mentioned prior art, and to provide a drug solid preparation for treating dysmenorrhea, to overcome the adverse effects of the liquid preparation on the human body due to ethanol, preservatives and a large amount of sucrose, and to To achieve the purpose of stable preparation, uniform dispersion of active ingredients, convenient administration and accurate dosage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation of Yikunning Tablets

[0018] Weigh 90g of angelica, 60g of Cyperus cyperi, 15g of cassia bark, 60g of Rehmannia glutinosa, 60g of white peony, 60g of Chuanxiong, 60g of Motherwort, 30g of Corydalis Corydalis, 15g of trigonum, and 15g of orange peel.

[0019] The above ten flavors are crushed into coarse powder, according to the percolation method under the item of liquid extract and extract, use 45% ethanol solvent, after immersion for 48 hours, slowly percolate at a speed of 1-3ml per minute, and collect the primary percolation The liquid is about 750ml, and the percolation is continued until the filtrate is nearly colorless, the first eluate is combined, and the filtrate is concentrated to a relative density of 1.06-1.12 (at 50° C.) to obtain a concentrated solution.

[0020] Add 80g of dextrin, filter, and spray dry. The air inlet temperature during spray drying is 170-180°C (preferably 180°C), the outlet air temperature is 70-80°C (preferably 80°C), and...

Embodiment 2

[0022] Preparation of Yikunning Capsules

[0023] The preparation process is the same as in Example 1, except that the granules are filled into capsules to obtain 400 capsules.

Embodiment 3

[0025] Preparation of Yikunning Granules

[0026] The preparation process is the same as in Example 1, except that the added forming agent is 120 g of lacto-oligosaccharide, dry granulated (material temperature below 60° C.), and granulated to obtain 200 g of brown-yellow granules with slight gas and sweet taste. Fill into bags, 1g per bag, to get 200 bags of granules.

[0027] During the specific preparation process:

[0028] Influence of Relative Density of Concentrate on Spray Drying Process

[0029] The spray drying efficiency of the liquid medicine is related to the concentration of the liquid medicine. According to Table 1, the relative density of the concentrated liquid is 1.06-1.12 (50°C) as the concentration end point.

[0030] Table 1 Effect of relative density of concentrate on spray drying process

[0031] Effect of relative density of concentrate on spray drying process

[0032] <1.06 The spray drying particles are too fine, the yield is low, a...

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PUM

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Abstract

The dysmenorrhea treating solid medicine preparation, named Yikunning, is prepared with angelica, nutagrass flatsedge rhizome, cassia bark, prepared rhizome of rehmannia, white peony root and other five kinds of Chinese medicinal materials; and it features its plasticizer of dextrin and / or lactose oligomer and the spray drying and dry pelletizing capable of maintaining the effective component completely and suitable for continuous GMP production. The medicine contains no ethanol, cane sugar and preservative, is safe, without side effect, and has many other advantages.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating blood deficiency and Qi stagnation, irregular menstruation, premenstrual and postmenstrual abdominal pain and lumbago, women's climacteric syndrome and a preparation method thereof. Background technique: [0002] With the acceleration of the pace of society and the increase of work pressure, irregular menstruation, premenstrual and menstrual abdominal pain have become common and frequently-occurring diseases in women. Modern chemical medicine lacks a safe, efficient and long-term medication for treating this type of disease. [0003] This type of traditional Chinese medicine preparation that has been available at present is a liquid tincture, the dosage form is backward, and the drug stability is poor; it contains preservatives and a large amount of sucrose, and the intake of preservatives and too much sugar is not good for the human body and affects the safe use of the preparation; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48A61P15/00A61P15/12
Inventor 濮桂宝李来润娄贯平张日武范弋陶良宝任军蒋小云
Owner 上海海虹实业(集团)巢湖今辰药业有限公司
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