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Encapsulation method for plastic micro-flow control analysis chip

A microfluidic analysis and encapsulation method technology, which is applied in the determination/inspection of microorganisms, biochemical equipment and methods, etc., can solve the problems of microchannel deformation, microchannel clogging of bonding methods, etc., and achieves high fidelity, High encapsulation strength, simple process effect

Inactive Publication Date: 2004-12-29
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a packaging method for plastic microfluidic analysis chips to overcome the problem of microchannel deformation in the current thermal packaging method and the microchannel blockage problem in the bonding method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Replication of microchannel patterns

[0019] A silicon or metal mold containing a microchannel convex pattern is installed on the upper part of the molding machine, and a 0.8mm thick polymethyl methacrylate (PMMA) substrate is placed on the bottom. The size of each side of the PMMA substrate is larger than the mold 8mm, and first raised When the temperature reaches 150°C, keep it under 1000N pressure for 60 seconds, then cool down, demould when the temperature drops to 60°C, open the cavity, take out the PMMA substrate with the microchannel pattern copied, and then drill holes in the corresponding position according to the microchannel pattern, A PMMA substrate with through holes and microchannel patterns was obtained.

[0020] (2) Preparation of PDMS sheets

[0021] Mix the PDMS prepolymer (produced by Rhodia, V-3040A) and the curing agent (V-3040B) at a ratio of 10:1. After vacuum degassing, cast it on a stainless steel mold, and then press a piece of glass on i...

Embodiment 2

[0025] (1) Replication of microchannel patterns

[0026] A silicon or metal mold containing microchannel convex patterns is installed on the upper part of the molding machine, and a 1.2mm thick polystyrene (PS) substrate is placed at the bottom, and the size of each side of the PS substrate is 9mm larger than the mold. First raise the temperature to 140°C, apply 2000N force and keep it for 90 seconds, then demould when cooled to 50°C, open the cavity, take out the PS substrate with the microchannel pattern copied, and then drill holes in the corresponding position according to the microchannel pattern , to obtain a PS substrate with through-holes and micro-channel patterns.

[0027] (2) Preparation of PDMS sheets

[0028] Mix PDMS prepolymer (produced by Rhodia, V-3040A) and curing agent (V-3040B) at a ratio of 12:1, and after vacuum degassing, cast it on a stainless steel mold, and then press a piece of glass on it. After curing at 70°C for 2.5 hours, the cured PDMS sheet w...

Embodiment 3

[0032] (1) Replication of microchannel patterns

[0033] A silicon or metal mold containing microchannel convex patterns is installed on the upper part of the molding machine, and a 1.5mm thick polycarbonate (PC) substrate is placed at the bottom, and the size of each side of the PC substrate is 10mm larger than the mold. First raise the temperature to 170°C, apply a force of 5000N and keep it for 120 seconds, then release the mold after cooling to 80°C, open the cavity, take out the PC substrate with the microchannel pattern copied, and then drill holes in the corresponding positions according to the microchannel pattern , to obtain a PC substrate with through-holes and micro-channel patterns.

[0034] (2) Preparation of PDMS sheets

[0035] Mix PDMS prepolymer (produced by Rhodia, V-3040A) and curing agent (V-3040B) at a ratio of 15:1. After vacuum degassing, cast it on a stainless steel mold, and then press a piece of glass on it. After curing at 80°C for 2 hours, remove ...

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PUM

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Abstract

The packing method for plastic chip for micro flow control includes copying the micro channel pattern via micro-copying process to plastic substrate, mixing dimethyl siloxane pre-polymer and curing agent in certain ratio, vacuum deairing, casting and curing to form polydimethyl siloxane set on the plastic substrate; painting ultraviolet cured adhesive around the substrate, adhering one layer of plastic sheet to constitute three-layer structure with raised packing strength; and irradiating with ultraviolet ray to complete the package of plastic chip. The present invention has simple technological process, less micro channel deformation, no jamming and very high packing strength.

Description

technical field [0001] The invention relates to a packaging method for a plastic microfluidic analysis chip, which uses the natural affinity between polydimethylsiloxane (PDMS: Polydimethylsiloxane) and plastics to complete the packaging of the chip without an adhesive, and belongs to the microfluidic analysis chip packaging method. Electromechanical systems (MEMS: Micro Electro Mechanical Systems) and analysis and detection technology field. Background technique [0002] Microfluidic analysis, also known as Lab on a chip, is a micro-separation analysis method that has risen rapidly in recent years. The core technology of this new method lies in the preparation of microfluidic analysis chip. Early people mainly used some inorganic materials (such as silicon, quartz, glass and ceramics, etc.), and used photolithography and chemical etching techniques to prepare microfluidic analysis chips (Seiler K., et al, Anal.Chem., 1993, 65, 1481 -1488.). This chip has good heat dissip...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 李建华陈迪刘景全朱军李以贵
Owner SHANGHAI JIAO TONG UNIV
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