The invention discloses a TFT-LCD panel, a color film substrate and a manufacturing method thereof, and the color film substrate comprises a transparent substrate and R, B and B resins, and the thicknesses of the R, the G and the B resins are sequentially gradually increased. By regulating the thicknesses of the R, the G and the B resins, the thickness of a liquid crystal layer in R, G and B pigments is changed, thereby leading the transmittances of the R, the G and the B pigments to be as close as possible; when a liquid crystal is driven by driving voltage preset in a program, the color which is closest to the theoretical gray value through the R, the G and the B pigments can be obtained, the degree of realism of the color can be improved, and the image quality of a liquid crystal display device can be improved.