Process of snthesizing medical biological degradative material by acetic acid organic guanidine as catalast

A technology of biodegradable materials and process methods, which is applied in the field of synthesis of medical biodegradable polyester polymers, can solve problems such as inability to remove tin-containing catalysts, cytotoxicity, and hidden dangers of safety, and achieve high yield and molecular weight distribution. Narrow, good polymer quality effect

Inactive Publication Date: 2005-01-05
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

At present, there is a relatively serious problem in the synthesis of such materials at home and abroad: divalent tin compounds, which are used in polymerization reactions and are recognized by the market as the best commercial catalysts for catalytic efficiency (such as: polylactic acid, poly The commercial catalyst stannous chloride of glycolic acid and tin protochloride-p-toluenesulfonic acid, the commercial catalyst stannous octoate) of

Method used

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  • Process of snthesizing medical biological degradative material by acetic acid organic guanidine as catalast
  • Process of snthesizing medical biological degradative material by acetic acid organic guanidine as catalast
  • Process of snthesizing medical biological degradative material by acetic acid organic guanidine as catalast

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Embodiment 1

[0016] In the reactor, 144 grams of lactide were charged, and 45.5 mg of hexabutylguanidine acetate catalyst was added according to monomer: catalyst=10000: 1 (molar ratio). Vacuumize the reactor, then replace it with nitrogen and repeat the operation three times, close the reactor under vacuum, heat the reactor slowly, and react at a constant temperature (110-120° C.) for 72 hours. After stopping the reaction, the reactor was cooled to room temperature, and then acetone was added to dissolve the polymer in the reactor. Deionized water was then added to precipitate the polymer. The water phase was filtered off, and finally the precipitate was dried in a vacuum oven at 50° C. for 24 hours under vacuum to obtain a white powdery solid with a yield of 99%. The polymer molecular weight is 2.0~4.0×10 4 , PDI≤1.20.

Embodiment 2

[0018] 144 grams of lactide were charged into the reactor, and 28.7 mg of tetramethyldibutylguanidine acetate catalyst was added according to monomer:catalyst=10000:1 (molar ratio). Vacuumize the reactor, then replace it with nitrogen and repeat the operation three times, close the reactor under vacuum, heat the reactor slowly, and react at a constant temperature (110-120° C.) for 72 hours. After stopping the reaction, the reactor was cooled to room temperature, and then acetone was added to dissolve the polymer in the reactor. Deionized water was then added to precipitate the polymer. The water phase was filtered off, and finally the precipitate was dried in a vacuum oven at 50° C. for 24 hours under vacuum to obtain a white powdery solid with a yield of 96.5%. The polymer molecular weight is 2.0~4.0×10 4 , PDI≤1.20.

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Abstract

The invention relates to a process method of synthesizing medical biodegradable material by bionic organic carbamidine catalyst, especially a new process method of synthesizing medical biodegradable polyester polymers, and its character: it uses nontoxic metal-free bionic acetic hexabutyl carbamidine and acetic tetramethyl dibutyl carbamidine as catalysts to make the ring-opening polymerization reaction of cyclo-ester monomers (L-lactide, D, L-lactide, glycollide, epsilon-caprolactone), thus synthesizing high-organism safety medical biodegradable materials. The new process method avoids cytotoxinic stannous octoate catalyst. The process adopts body polymerization method and the polymerization reaction has the characters of controlled and active polymerization reaction, not only able to synthesize homopolymers but also be used in synthesizing controlled composed block copolymer.

Description

technical field [0001] The invention relates to a process for synthesizing medical biodegradable materials using organic guanidine acetate (hexabutylguanidine acetate, tetramethyldibutylguanidine acetate) as a catalyst, especially a process for synthesizing medical biodegradable polyester polymers , belonging to the technical field of polymer chemistry. Background technique [0002] In recent years, with the rapid development of medicine and biological tissue engineering science, the international demand for medical biodegradable materials is increasing day by day. In terms of synthetic medical biodegradable materials, aliphatic polyesters (such as polylactic acid, polyglycolic acid and their copolymers, etc.) are the most valued, because such materials have excellent biodegradability and biocompatibility (no Body rejection effect) and biological safety (degradation products can participate in the glucose metabolism in the human body without residue), so it can be widely us...

Claims

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Application Information

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IPC IPC(8): C08G63/78C08G63/82
Inventor 李弘王晨宏王玉琴赵晓娜
Owner NANKAI UNIV
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