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Filter for cell

A cell filter, cell technology, applied in the direction of blood filtration, tissue cell/virus culture devices, biochemical instruments, etc., to achieve the effect of improving filtration efficiency, easy installation and portability, and small size

Inactive Publication Date: 2005-01-05
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no clinical device for directly separating tumor cells from blood and lymph

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prepare a layer of light-sensitive material on substrate materials such as silicon wafers, glass, ceramics, or metals, perform optical exposure according to the designed microstructure photomask, and form concave-convex results of light-sensitive materials on the substrate after development. Various microfluidic structures are prepared on the substrate by wet etching or dry etching, such as input and output channel ports, fluid blocking structures, fluid pools, fluid channels, etc. After completing the preparation of various structures, the devices prepared above are packaged with silicon wafers, glass plates, plastics, metal or ceramic plates. The surfaces of the above-mentioned materials are treated before or during use to make them biocompatible and not harmful to living organisms. After the device is packaged, the surface of the material inside the device is chemically treated to make it anti-coagulant.

Embodiment 2

[0039] Prepare a layer of light-sensitive material on substrate materials such as silicon wafers, glass, ceramics, or metals, perform optical exposure according to the designed microstructure photomask, and form concave-convex results of light-sensitive materials on the substrate after development. A layer of polymerizable polymer material (such as plastic, rubber, etc.) is coated on the above-mentioned concave-convex structure. After the polymer material is solidified, it is separated from the substrate, and various microfluidic structures are prepared on the surface of the polymer material, such as input and output channel ports, fluid blocking structures, fluid pools, fluid channels, etc. After completing the preparation of various structures, the devices prepared above are packaged with silicon wafers, glass plates, metal, plastic, rubber or ceramic plates. The surfaces of the above-mentioned silicon wafers, glass, ceramics, plastics or metals are treated before or during ...

Embodiment 3

[0041] According to the designed microstructure, the corresponding plastic or rubber precision molds are prepared. Direct application of micro-casting technology to prepare various plastic or rubber microfluidic structures, such as input and output channel ports, fluid blocking structures, fluid pools, fluid channels, etc. Epithelial cell antibodies are immobilized on the surface of the fluid pool to capture tumor cells. After the preparation of various structures is completed, assembly and packaging are carried out, and the materials used should be non-biologically toxic materials. After the device is packaged, the surface of the material inside the device is chemically treated to make it anti-coagulant.

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Abstract

The invention is a cell filter, a micro-fluid device for cell filtration and separation. It uses a closed fluid channel as a cavity, two ends of the cavity are provided with an fluid input port and an fluid output port, respectively, there is a cell filtering device, namely a cell particles stopper arranged between the two ports, and there is a fluid tank beside the stopper. The cell stopping mechanism can stop larger cells in the fluid and make them gather in the fluid tank, and they are caught by the related antibodies. By the external physical or chemical action, it makes them broken or inactivated, thus achieving the cell filtration. It can be used in eliminating tumor cells in the blood and has important application prospect in reducing transfer danger of tumor cells for the tumor patient operated, inhibiting proliferation and recrudescence of the tumors, improving the curative effect of tumor patients, etc.

Description

technical field [0001] The present invention is a kind of body fluid that can be used for separating blood, lymph fluid, and other fluids containing tiny particles such as cells, and can be used for on-site rapid separation, detection, inactivation and (or) crushing of tumor cells in particular to achieve removal of body fluids The invention relates to the purpose of tumor cells, belonging to the technical field of biomedical engineering equipment manufacturing. Background technique [0002] In recent years, tumor has become one of the major diseases threatening human health. Its incidence has increased substantially, and tumor occurrence tends to be younger. Tumor treatment is mainly surgery, radiotherapy, chemotherapy and other methods. However, the curative effect of these methods is limited at present, especially the cure rate of advanced patients is very low. [0003] A major factor in the development of tumor disease is the metastasis of...

Claims

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Application Information

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IPC IPC(8): A61M1/34C12M1/12C12M3/06
Inventor 陆祖宏魏于全肖鹏峰张盛友
Owner SOUTHEAST UNIV
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