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Novel preparation technique and formulation of 'Buzhon Yiqi'

A technology of invigorating the middle and nourishing qi and preparation technology, which is applied in the field of production technology of Chinese patent medicines, can solve the problems of difficult extraction of fat-soluble active ingredients, loss of volatile ingredients, slow dissolution of concentrated pills, etc., and achieves perfect and reasonable production technology Easy to carry and meet the effect of medication needs

Inactive Publication Date: 2005-01-26
毛友昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But making a general survey of the technology and preparations of the above-mentioned products all have weak points: (1) Buzhong Yiqi Pills (included in the Pharmacopoeia of the People's Republic of China 2000 edition one) its technology is: in the prescription, the eight flavor medicinal materials are pulverized into fine powder, Water pills are made from decoction of ginger and jujube; small honey pills are made by adding ginger and jujube decoction concentrate and refined honey; large honey pills are made by adding refined honey
Astragalus, Atractylodes macrocephala, Bupleurum, etc. are extracted by water in the concentrated pill process, some fat-soluble active ingredients are difficult to extract, and some volatile components in Atractylodes macrocephala, Bupleurum, etc. are also lost
At the same time, the concentrated pill has a large dosage. Although the prescription amount for one dose is reduced by about one-third of the pill, 8-10 pills still need to be taken each time, and the concentrated pill also has a slow dissolution rate and low bioavailability. lack of
[0003] To sum up, although there are many preparations for invigorating the middle and nourishing qi, they can not only fully retain the active ingredients of the prescribed Chinese medicinal materials to ensure the curative effect, but also achieve exquisite preparations and small dosage, which fully embodies the modernization of traditional Chinese medicine preparations. No

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Preparation of Buzhong Yiqi Capsules

[0028] Clean the ten herbs separately, remove impurities, and pass the test for later use; crush the ten herbs in the prescription into coarse powder for later use; take angelica, tangerine peel, ginger, Bupleurum, Codonopsis, and Atractylodes macrocephala, add water to distill, extract volatile oil, and use appropriate amount of non-toxic Dissolve in water and ethanol for later use; ultrafilter the distilled aqueous solution for later use; use 90% ethanol to heat and reflux the medicinal residues, Radix Astragali, Cimicifuga, and Jujube for 2 times; The first time, 2 hours each for the second time, and 1 hour for the third time, add the dregs of the above-mentioned astragalus and other ethanol extractions to the second decoction, combine the decoction, ultrafiltration, and the filtrate and the above-mentioned angelica after recovering ethanol The ethanol extract, angelica and other aqueous solutions are combined, vacuum...

Embodiment 2

[0029] Example 2: Preparation of Buzhong Yiqi Capsules

[0030] Clean the ten herbs separately, remove impurities, and pass the test for later use; crush the ten herbs in the prescription into coarse powder for later use; take angelica, tangerine peel, ginger, Bupleurum, Codonopsis, and Baizhu, add water to distill, extract volatile oil, and make- Cyclodextrin inclusion compound for later use; distilled aqueous solution for further use by ultrafiltration; medicine dregs, astragalus, cohosh, and jujube were heated and refluxed twice with 90% ethanol, and the extracts were combined, ultrafiltered, and ethanol was recovered from the filtrate for later use; licorice was added with water Decoct 3 times, 2 hours each for the first and second time, and 1 hour for the third time. Add the dregs of the above-mentioned astragalus and other alcohol-extracted herbs to the same decoction in the second decoction, combine the decoction, ultrafiltration, and the filtrate and the above-mentioned...

Embodiment 3

[0031] Embodiment 3: Preparation of Buzhong Yiqi Tablet

[0032]Clean the ten herbs separately, remove impurities, and pass the test for later use; crush the ten herbs in the prescription into coarse powder for later use; take angelica, tangerine peel, ginger, Bupleurum, Codonopsis, and Atractylodes macrocephala, add water to distill, extract volatile oil, and use appropriate amount of non-toxic Dissolve in water and ethanol for later use; ultrafilter the distilled aqueous solution for later use; use 90% ethanol to heat and reflux the medicinal residues, Radix Astragali, Cimicifuga, and Jujube for 2 times; The first time, 2 hours each for the second time, and 1 hour for the third time, add the dregs of the above-mentioned astragalus and other ethanol extractions to the second decoction, combine the decoction, ultrafiltration, and the filtrate and the above-mentioned angelica after recovering ethanol Combine the ethanol extract and angelica and other aqueous solutions, concentr...

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PUM

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Abstract

The invention discloses a novel preparation technique and formulation of 'Buzhong Yiqi' by modifying the conventional preparation making process with the modern pharmaceutical technologies, which can sufficiently sustain the active ingredient in the preparation.

Description

technical field [0001] The invention relates to the technical field of the preparation process of Chinese patent medicines, in particular to a new preparation process for invigorating the middle and replenishing qi and its preparation. Background technique [0002] Buzhong Yiqi Decoction is published in "Spleen and Stomach Theory", which is composed of sunburned astragalus, Codonopsis pilosula, roasted licorice, Atractylodes macrocephala, angelica, Cimicifuga, Bupleurum, and tangerine peel. , the function of raising yang and lifting depression, it has a significant effect on the symptoms of fatigue, fatigue, lack of food, abdominal distension, chronic diarrhea, prolapse of the anus, and uterine prolapse caused by weakness of the spleen and stomach, and depression of central qi. With the development of research on traditional Chinese medicine preparations, many colleagues in the medical field have carried out unremitting research and innovation on its ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/22A61K9/28A61K9/52A61K9/58A61P1/12A61P1/14
Inventor 毛友昌毛小敏
Owner 毛友昌
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