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Fluid magnetic purifier

A purifier and fluid technology, applied in chemical instruments and methods, suction equipment, chemical/physical processes, etc., to achieve the effects of less resources, easy installation and portability, and low mass production costs

Inactive Publication Date: 2005-01-26
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no clinical device for directly separating harmful substances from blood and lymph

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prepare a layer of light-sensitive material on substrate materials such as silicon wafers, glass, ceramics, or metals, perform optical exposure according to the designed microstructure photomask, and form concave-convex results of light-sensitive materials on the substrate after development. Two sets of parallel microfluidic structures are prepared on the substrate by wet etching or dry etching, such as input and output flow channel ports, fluid pool fluid channels, etc., and two stainless steel wires are fixed in the middle of the inflow and outflow ports. 50 micron magnetic microsphere barrier structure, a three-way valve is installed on the input and output ends, and a peristaltic pump is connected to the input end to improve the power of the fluid. A rotating magnetic field is applied to the outer end of the fluid pool. After completing the preparation of various structures, the devices prepared above are packaged with silicon wafers, glass plates, plastics, metal o...

Embodiment 2

[0037] Prepare a layer of light-sensitive material on substrate materials such as silicon wafers, glass, ceramics, or metals, according to the design

[0038] The planned microstructure photomask is subjected to optical exposure, and after development, the unevenness of the light-sensitive material is formed on the substrate. A layer of polymerizable polymer material (such as plastic, rubber, etc.) is coated on the above-mentioned concave-convex structure. After the polymer material is solidified, it is separated from the substrate, and two sets of parallel microfluidic structures are prepared on the surface of the polymer material, such as input and output channel ports, fluid pool fluid channels, etc., and the inflow and outflow ports are fixed in the middle Two magnetic microsphere barrier structures with a pore size larger than 50 microns woven by stainless steel wire, a three-way valve is installed at the input and output ends, and a peristaltic pump is connected to the i...

Embodiment 3

[0040] According to the designed microstructure, the corresponding plastic or rubber precision molds are prepared. Direct application of micro-casting technology to prepare various plastic or rubber microfluidic structures, such as input and output channel ports, fluid blocking structures, fluid pools, fluid channels, etc. Anti-low-density lipoprotein antibodies are immobilized on the surface of the magnetic microspheres in the fluid pool to capture harmful substances (such as harmful proteins, viruses, or harmful cells, etc.). After the preparation of various structures is completed, assembly and packaging are carried out, and the materials used should be non-biologically toxic materials. After the device is packaged, the surface of the material inside the device is chemically treated to make it anti-coagulant. The whole set of equipment is sterilized, and the aseptically operated magnetic microspheres connected with proteins (such as antibodies, receptors, antigens) are pla...

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PUM

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Abstract

A fluid magnetic cleaning device for removing fluid harmful substance by the magnetic particle is disclosed. It can be used for removing the harmful molecule, molecular aggregate, cell and other mini particles in blood, in particular for removing the harmful protein(like low density lipoprotein ), virus(like AIDS virus) and cell(like tumor cell). The cleaning device is integrated into a chip material as a fluid assembly with a fluid inlet and a fluid outlet. The end of the fluid inlet is connected with a pump(2), and the output end of the pump is connected with the inlet end channel selector(41) and a fluid pool(9) of the fluid reacting chamber. On the inlet end and outlet end, soft magnetic net or fence shape barrier are provided separately, active magnet microsperes are installed in the center of the fluid pool and a magnet control device is provided outside of the fluid pool. The output end of the fluid pool connects to the triple valve, while the output end of the channel selector connects to the purified fluid output.

Description

technical field [0001] The present invention is a harmful substance remover in fluid based on magnetic particles, which can be used to remove harmful molecules in fluids such as blood, molecular aggregates, and tiny particles such as cells, etc., especially can be used to remove harmful proteins in blood (such as low-density lipoprotein), viruses (such as HIV), cells (such as tumor cells), and belong to the technical field of biomedical engineering equipment manufacturing. Background technique [0002] In recent years, cardiovascular diseases and tumors have become major diseases that threaten human health. Its incidence has increased substantially, and its occurrence tends to be younger. Cardiovascular disease is mainly controlled with drugs, which can only slow down the further development of the disease. Tumor treatment is mainly surgery, radiotherapy, chemotherapy and other methods. The therapeutic effect is limited, especially the cure rat...

Claims

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Application Information

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IPC IPC(8): A61M1/00A61M1/34A61M1/36B01D35/00B01D37/00B01J19/00
Inventor 郭小英王永宁唐祖明陆祖宏张春秀杨玉志张盛友
Owner SOUTHEAST UNIV
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