Fluid magnetic purifier

A purifier and fluid technology, applied in chemical instruments and methods, suction equipment, chemical/physical processes, etc., to achieve the effects of less resources, easy installation and portability, and low mass production costs

Inactive Publication Date: 2005-01-26
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no clinical device for directl

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034] Example 1:

[0035] A layer of photosensitive material is prepared on the substrate material such as silicon wafer, glass, ceramic, or metal, and optical exposure is carried out according to the designed micro-structure photomask. After development, the concave and convex result of the photosensitive material is formed on the substrate. Two sets of microfluidic structures in parallel are prepared on the substrate by wet etching or dry etching, such as input and output channel ports, fluid pool fluid channels, etc. The inflow and outflow ports are fixed with two stainless steel wires woven with a larger diameter With a 50-micron magnetic microsphere barrier structure, a three-way valve is installed at the input and output ends, and a peristaltic pump is connected at the input end to increase the power of the fluid. A rotating magnetic field is added to the outer end of the fluid cell. After the various structures are prepared, the devices prepared above are packaged with sil...

Example Embodiment

[0036] Example 2:

[0037] Prepare a layer of light-sensitive material on substrate materials such as silicon wafers, glass, ceramics, or metals.

[0038] The calculated microstructure photomask is subjected to optical exposure, and after development, the concave-convex result of the photosensitive material is formed on the substrate. Coating a layer of polymerizable polymer material (such as plastic, rubber, etc.) on the above-mentioned uneven structure. After the polymer material is cured, it is separated from the substrate, and two sets of parallel microfluidic structures are prepared on the surface of the polymer material, such as input and output channel ports, fluid pool fluid channels, etc., fixed in the middle of the inflow and outflow ports Two magnetic microsphere barrier structures with a pore size larger than 50 microns woven by stainless steel wires, a three-way valve is installed at the input and output ends, and a peristaltic pump is connected at the input end to in...

Example Embodiment

[0039] Example 3:

[0040] According to the designed microstructure, a corresponding plastic or rubber precision mold is prepared. Direct application of micro-casting technology to prepare various plastic or rubber microfluidic structures, such as input and output channel ports, fluid barrier structures, fluid pools, fluid channels, etc. Anti-low density lipoprotein antibodies are immobilized on the surface of the magnetic microspheres in the fluid pool to capture harmful substances (such as harmful proteins, viruses, or harmful cells, etc.). After the various structures are prepared, they are assembled and packaged. The materials used should be non-biologically toxic materials. After the device is packaged, the surface of the material in the device is chemically treated to make it anti-blood coagulation. The whole set of equipment is sterilized, and the aseptic magnetic microspheres connected with proteins (such as antibodies, receptors, and antigens) are placed between the two m...

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PUM

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Abstract

A fluid magnetic cleaning device for removing fluid harmful substance by the magnetic particle is disclosed. It can be used for removing the harmful molecule, molecular aggregate, cell and other mini particles in blood, in particular for removing the harmful protein(like low density lipoprotein ), virus(like AIDS virus) and cell(like tumor cell). The cleaning device is integrated into a chip material as a fluid assembly with a fluid inlet and a fluid outlet. The end of the fluid inlet is connected with a pump(2), and the output end of the pump is connected with the inlet end channel selector(41) and a fluid pool(9) of the fluid reacting chamber. On the inlet end and outlet end, soft magnetic net or fence shape barrier are provided separately, active magnet microsperes are installed in the center of the fluid pool and a magnet control device is provided outside of the fluid pool. The output end of the fluid pool connects to the triple valve, while the output end of the channel selector connects to the purified fluid output.

Description

technical field [0001] The present invention is a harmful substance remover in fluid based on magnetic particles, which can be used to remove harmful molecules in fluids such as blood, molecular aggregates, and tiny particles such as cells, etc., especially can be used to remove harmful proteins in blood (such as low-density lipoprotein), viruses (such as HIV), cells (such as tumor cells), and belong to the technical field of biomedical engineering equipment manufacturing. Background technique [0002] In recent years, cardiovascular diseases and tumors have become major diseases that threaten human health. Its incidence has increased substantially, and its occurrence tends to be younger. Cardiovascular disease is mainly controlled with drugs, which can only slow down the further development of the disease. Tumor treatment is mainly surgery, radiotherapy, chemotherapy and other methods. The therapeutic effect is limited, especially the cure rat...

Claims

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Application Information

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IPC IPC(8): A61M1/00A61M1/34A61M1/36B01D35/00B01D37/00B01J19/00
Inventor 郭小英王永宁唐祖明陆祖宏张春秀杨玉志张盛友
Owner SOUTHEAST UNIV
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