Oral disintegrants of nimodipine and their preparation

A nimodipine oral cavity and nimodipine technology, which is applied to the oral disintegrating tablet of nimodipine and the field of preparation thereof, can solve the problems of unwillingness to take esophagus, inappropriate crystal form of active pharmaceutical ingredients, poor dissolution, etc. Effects of good taste, good dissolution and bioavailability

Inactive Publication Date: 2005-02-23
范敏华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these dosage forms have several problems when taking
For example, the crystal form of the active ingredient of the drug used is not appropriate, and the drug has not been dispersed in a solid, resulting in poor dissolution and low bioavailability; the elderly and young children with...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Solid Dispersion Prescription:

[0019] Raw material name Feed amount

[0020] Nimodipine 200g

[0021] Polyvinylpyrrolidone 200g

[0022] Cross-linked polyvinylpyrrolidone 800g

[0023] Microcrystalline Cellulose 950g

[0024] Absolute ethanol 1000ml

[0025] Tablet prescription:

[0026] Material name Feed amount

[0027] Solid dispersion 21.5g

[0028] Microcrystalline Cellulose 20g

[0029] Mannitol 42g

[0030] Cross-linked polyvinylpyrrolidone 4g

[0031] Low-substituted hydroxypropyl cellulose 6g

[0032] Aspartame 3g

[0033] Sweet orange essence 1g

[0034] Precipitated silica 2g

[0035] Magnesium stearate 0.5g

[0036] Dissolve nimodipine and polyvinylpyrrolidone in absolute ethanol according t...

Embodiment 2

[0046] Solid Dispersion Prescription:

[0047] Raw material name Feed amount

[0048] Nimodipine 200g

[0049] Polyvinylpyrrolidone 300g

[0050] Cross-linked polyvinylpyrrolidone 800g

[0051] Microcrystalline Cellulose 850g

[0052] Absolute ethanol 2000ml

[0053] Tablet prescription:

[0054] Material name Feed amount

[0055] Solid dispersion 21.5g

[0056] Microcrystalline Cellulose 20g

[0057] Mannitol 42g

[0058] Cross-linked polyvinylpyrrolidone 4g

[0059] Croscarmellose Sodium 6g

[0060] Aspartame 3g

[0061] Sweet orange essence 1g

[0062] Precipitated silica 2g

[0063] Magnesium stearate 0.5g

[0064] Dissolve nimodipine and polyvinylpyrrolidone in absolute ethanol according to the prescription quantity, stir and dissolve evenly, then stir and mix the two evenly; take cross-linked polyvinylpyrrolidone and microcrystalline cellulose according to the prescription quantity, sieve and put...

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PUM

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Abstract

An oral disintegrating tablet of nimodipine is prepared from nimodipine, carrier, adsorbent, disintegrant, filler, soluble polybasic alcohol, and other auxiliaries.

Description

technical field [0001] The invention relates to a dosage form of nimodipine, in particular to an orally disintegrating tablet of nimodipine and a preparation method thereof. technical background [0002] Nimodipine is an insoluble polymorphic drug with a large first-pass effect, low bioavailability in vivo, and uncertain curative effect. In recent years, the crystal form phenomenon of drugs has also attracted great attention. With the deepening of research, it is found that the crystal form of a drug has a great relationship with the curative effect, dissolution rate, bioavailability, and stability of the drug. The research on the polymorphic form of the drug and the selection of the appropriate drug crystal form are beneficial to the transformation of the drug. In order to improve clinical efficacy and reduce toxic and side effects. Using solid dispersion technology to highly disperse drugs with appropriate crystal forms into water-soluble polymer ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4422A61K47/10A61K47/38A61P9/10A61P9/12
Inventor 范敏华
Owner 范敏华
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