Simple prescription of earthworm oral liquid for treating alveolar bone resorption and its preparing method

A technology of Dilong oral liquid and single formulation, which can be used in bone diseases, pharmaceutical formulations, liquid delivery, etc., can solve the problems of lack of bone regeneration, no experimental verification, etc., and achieve the effects of promoting fracture healing, low price, and convenient material acquisition.

Inactive Publication Date: 2005-03-16
陈莉丽 +1
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  • Claims
  • Application Information

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Problems solved by technology

But it is a pity that people have not yet had an accurate understanding of the curative effect of earthworm, especially the lack of research on whether the single prescription earthworm can effectively inhibit bone resorption and promote bone regeneration, and there is no experimental verification. It is impossible to make the single-dose Dilong with many active ingredients recorded in the Pharmacopoeia into a finished medicine for the treatment of alveolar bone resorption and other orthopedic diseases

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  • Simple prescription of earthworm oral liquid for treating alveolar bone resorption and its preparing method
  • Simple prescription of earthworm oral liquid for treating alveolar bone resorption and its preparing method
  • Simple prescription of earthworm oral liquid for treating alveolar bone resorption and its preparing method

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Embodiment 1

[0014] Embodiment 1, the present embodiment treats the unilateral Dilong oral liquid for the treatment of alveolar bone resorption, is a kind of Dilong water extract that can measure its polysaccharide content more than 10% (weight) by gel permeation chromatography test method or alcoholic extract.

[0015] The preparation method of above-mentioned single prescription earthworm oral liquid is: 1) get a kind of earthworm, and its Latin name is Pheretimaguillelmi, belongs to the dry body of genus genus ginseng or earthworm; first through cleaning, Dry and pulverize into powder; 2) take the extract, which is distilled water or 95% ethanol purchased from outside, and then mix the earthworm powder with distilled water or 95% ethanol in a ratio of 1:10 (W:V) Mix and reflux in boiling water for 3 to 10 hours, then perform coarse filtration, and add distilled water or 95% ethanol to the filter residue in the above ratio, then carry out boiling water reflux for 3 to 10 hours, and then ...

Embodiment 2

[0085] Embodiment 2. The single prescription Dilong used in this embodiment for the treatment of alveolar bone resorption can be taken orally, and it can also be compounded with a medicinal sustained-release medium to form a sustained-release drug that can be placed in the periodontal pocket to treat periodontitis. The preparation method of the slow-release medicine is to mix the uniprescription dilong oral liquid with a medicinal slow-release medium, such as hydroxyethyl cellulose, magnesium chloride, etc., and then make an ointment or gel or a slow-release film according to a conventional method. When using the sustained-release medicine, it is only necessary to place it in the periodontal pocket, so that the sustained-release medicine exerts a continuous effect on the periodontal tissue in this local area in the oral cavity. It not only helps to control and treat local diseases, but also the drug will not irritate the normal parts of the oral cavity.

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Abstract

The invention discloses a simple prescription of earthworm oral liquid for treating alveolar bone resorption and its preparing method which consists of, cleaning, drying and disintegrating earthworms, mixing with distilled water or 95% ethanol by 1:10 (W:V), boiled water reflux, coarse straining, subjecting the slag to boiled water reflux, coarse straining, merging the two filtrates, evaporating and concentrating.

Description

technical field [0001] A drug for treating inflammatory alveolar bone resorption and other osteoclastic bone resorption diseases or osteoporotic diseases, especially a single agent capable of blocking alveolar bone resorption or promoting alveolar bone regeneration Long oral liquid and its preparation method. Background technique [0002] As we all know, bone metabolism is a dynamic balance process between osteoblasts and osteoclasts, and the imbalance of this balance will lead to bone metabolic diseases, such as periodontitis, which is one of the most common oral diseases in the population of various countries, and one of its main pathological changes It is the absorption of alveolar bone, which leads to loosening or even loss of teeth. Alveolar bone is the bone tissue with the most active metabolism in human bones. Under normal physiological conditions, the balance of osteoblasts and osteoclasts maintains the stability of alveolar bone metabolism; however, during periodon...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/06A61K9/08A61K9/70A61K35/62A61P1/02A61P19/08
Inventor 陈莉丽严杰唐琪
Owner 陈莉丽
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