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Ginger extract preparation

A ginger extract and preparation technology, which is applied in the production field of ginger extract preparations, can solve the problems of loss of gingerol stability and inability to prevent dehydration, and achieve the effect of increased stability

Inactive Publication Date: 2005-05-11
FINZELBERG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage is that the herbal auxiliaries (oils, lipids) used here do not prevent dehydration, which makes gingerol less stable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Comparative Example 1-Sample A: Unstabilized concentrated extract of ginger (extract Zingiberise rhiz.spir.spiss.)

[0043] 50 kilograms of ginger rhizomes, chopped and sieved into small pieces of 6-8mm, use 500 kilograms of ethanol 96% [V / V] to infiltrate thoroughly. The production temperature does not exceed 45°C. The filtrate, ethanol mobile phase were combined and gently concentrated in vacuo at 45°C to form a paste extract.

Embodiment 2

[0044] Example 2-Sample B: Preparation of ginger, stabilized with Colidan 25

[0045] 45.5 grams of the starting extract-similar to the preparation of sample A (extract Zingiberis e rhiz.spir.spiss.), with a dry solids content of 33%-equivalent to 15 grams of dry extract-it uses more than 99% ethanol Dilute to 20% dry solids. Stir vigorously for 15 minutes- Solution 1 .

[0046] 99.75 grams of Coledan 25 are diluted with more than 99% ethanol with stirring to 10% dry solids. Stir vigorously for 30 minutes- Solution 2 .

[0047] The two solutions were mixed in proportions under stirring at room temperature, resulting in a clear red-brown solution. Stirring was carried out for 30 minutes, and the mixture was gently concentrated in a rotary evaporator at a maximum temperature of 45°C in a water bath. The obtained extract preparation was evaporated to no solvent, and dried in a drying oven at 45°C under vacuum. Add 5% silica as an auxiliary.

[0048] Sample

Analysis p...

Embodiment 3

[0070] The concentrated ginger extract produced similarly to Comparative Example 1 contains 15.8% of the total pungent substances and 15.1% of essential oils (natural DER 12:1). For this, 10.0 kg of spissum extract is absorbed by 10.0 kg of diatomaceous earth and the production volume is 10 kg / kg mixture using carbon dioxide extraction. The anhydrous yield of oily ginger extract accounts for 34% of the extract used. The obtained ginger oleosomes contained 22.7% of the total pungent substances and 39.0% of essential oils (DER natural 35:1).

[0071] 15 grams of ginger oleosomes are diluted with >99% ethanol to contain 20% dry solids. Stir for 30 minutes until a homogeneous solution is obtained- Solution 1 . 85 grams of Collidan 25 was diluted with >99% ethanol and stirred until it contained 10% dry solids. Stir vigorously for 30 minutes- Solution 2 .

[0072] The two solution parts were stirred at room temperature and mixed in proportion to obtain a red-brown, clear solution. Stir...

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PUM

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Abstract

The invention relates to stable ginger extract preparations, characterized by having a content of a native ginger extract and of at least one stabilizing auxiliary agent selected from the group of proton-capturing substances, whereby the chemically stabilizing auxiliary agent preferably belongs to the family of polyvinylpyrrolidones and releases the included pungent agents in solution. Stable ginger extract preparations having large amounts of pharmaceutically relevant pungent agents or essential oils are additionally obtained by carefully carrying out method steps, which are relevant to the production, at a temperature of no greater than 45° C. The inventive preparations remain analytically stable over a long period of time of up to 18 months and longer. The invention also relates to solid galenic dosage forms such as capsules, tablets and dragees all of which containing the stable ginger extract preparations.

Description

Technical field [0001] The invention relates to a ginger extract preparation, which has the characteristics of a stable extraction preparation for a longer period of time, that is, more than 18 months or more, and the invention relates to a production method of a ginger extract preparation. The present invention also describes stable herbal preparations containing ginger extract preparations, such as capsules, coated tablets and tablets, and their applications. Background technique [0002] Ginger (Zingiber officinale), known as a healing and flavoring plant for centuries, has become increasingly important in the pharmaceutical industry and nutritional supplements in recent years. A preparation obtained from the rhizome zingiberis of ginger, the drug powder itself and the extract recovered therefrom are used to treat symptoms of dyspepsia and travel disease (see Langner, E. et al.: Balance 1, 5-16 , An overview of the literature in October 1997). Earlier, the agent E of the Feder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/28A61K9/48A61K31/12A61K36/00A61K36/18A61K36/9068A61K47/04A61K47/12A61K47/32A61K47/36A61K47/38A61P1/08A61P1/14A61P3/02A61P3/10A61P29/00
CPCA61K9/2027A61K9/4866A61K36/9068A61K47/32A61P1/08A61P1/14A61P29/00A61P3/02A61P3/10
Inventor F·格迪克B·法伊斯特尔
Owner FINZELBERG
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