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Nanometer oleanolic acid powder for injection and preparation method thereof

A technology for oleanolic acid and injection, which is applied in the field of nano-oleanolic acid powder injection for injection and its preparation field, can solve the problems of slow dissolution rate, low bioavailability, can not be improved and outstanding, etc. The effect of reducing side effects, simple preparation method and easy control of process route

Inactive Publication Date: 2005-06-22
杨唐玉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The dosage forms of oleanolic acid currently used clinically include tablet, capsule and solid dispersible tablet. Since oleanolic acid is insoluble in water, the dissolution rate is slow and the bioavailability is low.
The nano-gansukang preparation and its preparation method disclosed in patent application 01102527 is a compound preparation, but it cannot be obtained from its published application documents that its effect has significant progress and outstanding features compared with traditional ones

Method used

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  • Nanometer oleanolic acid powder for injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0015] The process route shown in the accompanying drawing: Dissolve 0.25g of oleanolic acid and 8g of soybean lecithin with 150ml of acetone or chloroform or ethanol or methanol and filter to obtain solution A; Solution B, and heated to 55-65°C on a water bath; under stirring conditions, add oleanolic acid in acetone or chloroform or ethanol or methanol solution A, keep warm on a water bath for 2 hours; evaporate acetone or Chloroform or ethanol or methanol to obtain solution C; dissolve 300g of mannitol and 300g of glucose in 500ml of distilled water, mix and dissolve with solution C, set the volume to 5000ml, and divide into vials, 5ml per bottle, filled with neat Fruit acid 2.5 mg, freeze-dried to obtain the finished product.

Embodiment 2

[0017] The process route shown in the accompanying drawing: Dissolve 0.5g of oleanolic acid and 10g of soy lecithin with 200ml of acetone or chloroform or ethanol or methanol and filter to obtain solution A; dissolve 10g-15g of poloxamer with 4000ml of distilled water, and filter Solution B, and heated to 55-65°C on a water bath; under stirring conditions, add oleanolic acid in acetone or chloroform or ethanol or methanol solution A, keep warm on a water bath for 2 hours; evaporate acetone or Chloroform or ethanol or methanol to obtain solution C; dissolve 350g of mannitol and 300g of glucose in 500ml of distilled water, mix and dissolve with solution C, set the volume to 5000ml, and divide into vials, 5ml per bottle, filled with neat 5 mg of fruit acid was freeze-dried to obtain the finished product. (with or without hyperosmotic treatment)

Embodiment 3

[0019] The process route shown in the attached figure: Dissolve 1 g of oleanolic acid and 15 g of soybean lecithin with 150 ml of acetone or chloroform or ethanol or methanol and filter to obtain solution A; dissolve 15 g to 20 g of poloxamer with 4000 ml of distilled water and filter to obtain solution B, and heated to 55-65°C on a water bath; under stirring conditions, add oleanolic acid in acetone or chloroform or ethanol or methanol solution A, keep warm on a water bath for 2 hours; distill off acetone or tristimulus under reduced pressure Chloromethane or ethanol or methanol to obtain solution C; dissolve 450g of mannitol and 300g of glucose in 500ml of distilled water, mix and dissolve with solution C, set the volume to 5000ml, and divide into vials, 5ml per bottle, containing olean fruit acid 10mg, freeze-dried to obtain the finished product.

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Abstract

The invention provides a nano oleanolic acid powder for injection and preparation method, wherein the powder injection comprises the principal raw materials (by weight portion) of, active oleanolic acid 0.1-0.8, bean phospholipin 0.5-15 as carrier and / or poloxamer 1-20 as surface active agent, and freeze-drying adjuvant 60-750g.

Description

technical field [0001] The invention belongs to oleanolic acid pharmaceutical preparations, in particular to nano oleanolic acid powder for injection with liver-targeting property and a preparation method thereof. Background technique [0002] The dosage forms of oleanolic acid currently used clinically include three dosage forms of tablet, capsule and solid dispersible tablet. Since oleanolic acid is insoluble in water, its dissolution rate is slow and its bioavailability is low. The nano-gansukang preparation drug disclosed in patent application 01102527 and its preparation method is a compound preparation, but it can not be obtained from its published application documents that its effect has significant progress and outstanding features compared with traditional ones. Contents of the invention [0003] The object of the present invention is to provide a nano-sized oleanolic acid freeze-dried powder injection and its preparation method, so that it has a high degree of l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/56A61K31/704A61P1/16
Inventor 易以木杨唐玉
Owner 杨唐玉