Dispersible tablet of doxifluridine

A technology for doxifluridine and dispersible tablets, which is applied in the fields of pill delivery, organic active ingredients, and medical preparations containing active ingredients, etc., which can solve the problems of difficult development and achieve more absorption points, faster absorption, and improved drug use. compliance effect
CN1634117AActive Publication Date: 2005-07-06LUNAN PHARMA GROUP CORPORATION
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LUNAN PHARMA GROUP CORPORATION
Publication Date
2005-07-06

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Abstract

The present invention provides a dispersible tablet dosage form of doxifluridine, which is characterized by its speedy decentralization and dissolution when being in vitro. Through clinical applications, it is found that compared to common doxifluridine capsules, the clinical curative effect is considerably improved, at the same time the adverse reaction is remarkably reduced and unexpected effects are acquired. In accordance with the present invention, for extensive cancer patients executing chemotherapy by adopting doxifluridine, the pains of chemotherapy are considerably alleviated, the neoplastic chemotherapy effect is improved, and said medicine has prodigious clinical use values; 5-FU is a specific anti-metabolizing medicine during the S period, and the unexpected effects obtained in accordance with the present invention are of good enlightening significance for researching pharmacodynamics features and mechanism of action of doxifluridine. In addition, it is convenient for aged and children to take the medicine in accordance with the present invention, with stable formulation, fast absorption, high bioavailability and few adverse reaction, which can be used as medicine for treating breast carcinoma, cancer of stomach, carcinoma of colon, restocarcinoma, nasopharyngeal carcinoma and the like.
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Description

technical field

[0001] The invention belongs to the technology of pharmaceutical preparations. Background technique

[0002] Cancer is a serious disease that threatens human life. In developed countries, about 1 / 3 of people develop tumors at different stages of their lives, and about 1 / 4 of them die of tumors, and lung cancer is the first cause of death. Gastric cancer has the highest incidence rate in my country, followed by lung cancer, intestinal cancer and breast cancer. The occurrence and death of cancer are becoming more and more serious, and it has become the first cause of death in some areas. Therefore, the study of anticancer drugs has attracted more and more attention. my country has listed cancer research as one of the 38 key scientific and technological projects.

[0003] Doxifluridine, also known as deoxyfluridine, 5-DFUR, is the precursor of 5-FU (5-fluorouracil). It was synthesized by the American branch of Roche in the 1970s with the trade name of Furtul...

Claims

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