Dispersible tablet of doxifluridine

A technology for doxifluridine and dispersible tablets, which is applied in the fields of pill delivery, organic active ingredients, and medical preparations containing active ingredients, etc., which can solve the problems of difficult development and achieve more absorption points, faster absorption, and improved drug use. compliance effect

Active Publication Date: 2005-07-06
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to some specific physical and chemical properties of doxifluridine, it is difficult to develop, and now there are only some common capsules and tablets for patients to use

Method used

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  • Dispersible tablet of doxifluridine
  • Dispersible tablet of doxifluridine
  • Dispersible tablet of doxifluridine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0014] Embodiment (prescription quantity is 1000):

[0015] Eight specific prescriptions:

[0016] Prescription A:

[0017] Doxifluridine 20g

[0018] Hydroxypropylcellulose (disintegrant) 96g

[0019] Magnesium stearate (lubricant) 1.5g

[0020] Micronized silica gel (flow aid) 2.5g

[0021] Preparation process: the main drug is passed through a 100-mesh sieve, the disintegrant is passed through a 80-mesh sieve, the prescribed amount of the main drug and the disintegrant are weighed and mixed evenly, the prescribed amount of lubricant is added, mixed evenly, and tabletted to obtain the product. Dispersible tablet dispersion time limit is 1.0min.

[0022] Prescription B:

[0023] Doxifluridine 60g

[0024] Hydroxypropyl cellulose (disintegrant) 108g

[0025] 10% starch slurry (adhesive) 100g

[0026] Magnesium stearate (lubricant) 2g

[0027] Preparation process: The main drug is passed through a 100-mesh sieve, and the disintegrant is passed through a 80-mesh sieve....

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Abstract

The present invention provides a dispersible tablet dosage form of doxifluridine, which is characterized by its speedy decentralization and dissolution when being in vitro. Through clinical applications, it is found that compared to common doxifluridine capsules, the clinical curative effect is considerably improved, at the same time the adverse reaction is remarkably reduced and unexpected effects are acquired. In accordance with the present invention, for extensive cancer patients executing chemotherapy by adopting doxifluridine, the pains of chemotherapy are considerably alleviated, the neoplastic chemotherapy effect is improved, and said medicine has prodigious clinical use values; 5-FU is a specific anti-metabolizing medicine during the S period, and the unexpected effects obtained in accordance with the present invention are of good enlightening significance for researching pharmacodynamics features and mechanism of action of doxifluridine. In addition, it is convenient for aged and children to take the medicine in accordance with the present invention, with stable formulation, fast absorption, high bioavailability and few adverse reaction, which can be used as medicine for treating breast carcinoma, cancer of stomach, carcinoma of colon, restocarcinoma, nasopharyngeal carcinoma and the like.

Description

technical field [0001] The invention belongs to the technology of pharmaceutical preparations. Background technique [0002] Cancer is a serious disease that threatens human life. In developed countries, about 1 / 3 of people develop tumors at different stages of their lives, and about 1 / 4 of them die of tumors, and lung cancer is the first cause of death. Gastric cancer has the highest incidence rate in my country, followed by lung cancer, intestinal cancer and breast cancer. The occurrence and death of cancer are becoming more and more serious, and it has become the first cause of death in some areas. Therefore, the study of anticancer drugs has attracted more and more attention. my country has listed cancer research as one of the 38 key scientific and technological projects. [0003] Doxifluridine, also known as deoxyfluridine, 5-DFUR, is the precursor of 5-FU (5-fluorouracil). It was synthesized by the American branch of Roche in the 1970s with the trade name of Furtul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7072A61P35/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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