Drop pills of arenobufagin and preparation method

A technology of toad flakes and dropping pills is applied in the directions of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. Protection and environmental protection, faster dissolution and absorption, improved bioavailability

Inactive Publication Date: 2005-08-31
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0007] Due to the limitations of existing injection preparation technology and the influence of the complexity of traditional Chinese medicine ingredients, traditional Chinese medicine injections are often prone to acute allergic reactions or adverse reactions. At the same time, there are also difficulties in operation, great pain for patients, high manufacturing and medical costs, and inconvenient transportation and storage. , heavy economic burden for patients, unsuitable for family use and other disadvantages
[0008] In addition, due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicines, have long dissolution time, low dissolution rate, poor absorption, h...

Method used

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Examples

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Embodiment Construction

[0029] Now with several groups of specific examples, the preparation method of Chansu dripping pills of the present invention will be further described.

[0030] Group 1: Tests with a single matrix

[0031] 1. Preparation of medicinal extract: Take an appropriate amount of toad venom in g or kg, soak in 10 times the amount of water, grind, add ethanol to make the alcohol content exceed 75%, stir well, let stand, refrigerate for 24 hours, filter, Recover ethanol from the filtrate until it has no alcohol smell, concentrate it under reduced pressure (0.1MPa) and low temperature (60°C) to form a thick paste with a relative density of 1.3-1.35, or continue to dry it and crush it into a dry powder to obtain the product;

[0032] 2. Substrate: polyethylene glycol (2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. One or a mixture of...

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Abstract

A dripping pill of toad venom for treating pyogenic infection or as the auxiliary anticancer medicine is prepared from toad venom and medicinal carrier.

Description

technical field [0001] The invention relates to a pharmaceutical composition with heat-clearing and detoxifying effects for treating acute and chronic suppurative infections, or as an anti-tumor auxiliary drug, in particular to an oral preparation of a pharmaceutical composition prepared from the traditional Chinese medicine Chan Su. Background technique [0002] According to the ministerial drug standard WS 3 - Hedyotis diffusa injection prepared by the preparation method given in B-3354-98 is a kind of liquid that has the functions of clearing away heat and detoxification, promoting dampness and reducing swelling, and is used for the treatment of acute and chronic suppurative infections, or as an anti-tumor The pure Chinese medicine injection for auxiliary medicine has been clinically verified and has definite curative effect. It is a commonly used medicine for clinical and family treatment of such diseases. [0003] The following is the drug standard WS 3 -Formulation a...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K35/65A61P31/00A61P35/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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