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Method for extracting vitexin, use and preparation

An extraction method and vitexin technology, which are applied in the directions of medical preparations containing active ingredients, chemical instruments and methods, pill delivery, etc., can solve the problems of lack of scientific refinement, purification process, mixed ingredients, and different degrees of absorption, etc. To achieve the effect of reducing ejection resistance, reducing blood viscosity and increasing blood flow

Active Publication Date: 2005-10-19
安徽九方制药有限公司
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AI Technical Summary

Problems solved by technology

[0002] Hawthorn, a commonly used Chinese herbal medicine, has a history of thousands of years in China. Hawthorn leaf extract is made into tablets, mainly for oral use, but lacks scientific refining and purification processes. The ingredients are mixed and the content is different. It is absorbed after use. The degree is different, the dosage is difficult to control, and the curative effect is affected

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0012] Extraction of vitexin:

[0013] 1. Add water to decoct the hawthorn leaves 1 to 3 times, and add 6 to 12 times the amount of water.

[0014] 2. Combine the decoctions and concentrate to liquid extracts, the weight ratio of medicinal materials: extracts=1~3:1~3:1.

[0015] 3. Add ethanol for precipitation, and pour out the alcohol after standing for several hours. The amount of ethanol added is 2 to 6 times, and the time is 12 to 36 hours.

[0016] 4. Ethanol is recovered under reduced pressure and concentrated into a liquid extract.

[0017] 5. Add the liquid extract above into water, and add hydrochloric acid to adjust the pH of the solution to 0.6-1 for hydrolysis.

[0018] 6. Refrigerate the hydrolyzed solution for 3 to 6 days to precipitate crystals. Refrigeration temperature = 0 ~ 10 ℃.

[0019] 7. Take the crystals and recrystallize with ethanol.

[0020] 8. The obtained vitexin is made into small water injection, freeze-dried powder and tablets, capsules and...

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Abstract

The present invention discloses the extraction process of vitexin and the extraction process includes the following steps: obtaining coarse haw leaf extract, hydrolyzing the coarse haw leaf extract in water solution of strong acid, separating crystal, and re-crystallization to obtain the product vitexin. The vitexin product has purity over 98%, and may be used in preparing instilment liquid, freeze dried powder, tablet, capsule or dripping pill applied in the treatment of cardiac vascular diseases, including coronary heart disease, myocardial infarction and angina pectoris.

Description

technical field [0001] The invention belongs to the active ingredients of traditional Chinese medicine, in particular to the extraction method, application and preparation of vitexin in hawthorn leaves. Background technique [0002] Hawthorn, a commonly used Chinese herbal medicine, has a history of thousands of years in China. Hawthorn leaf extract is made into tablets, mainly for oral use, but lacks scientific refining and purification processes. The ingredients are mixed and the content is different. It is absorbed after use. The degree is different, the dosage is difficult to master, and the curative effect is affected. Contents of the invention [0003] The object of the present invention is to provide an extraction method, application and preparation of vitexin, an active ingredient of hawthorn leaves, to obtain high-purity vitexin monomer, to make intravenous medicine and oral administration, and to clinically treat coronary heart disease, myocardial Cardiovascular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K9/20A61K9/48A61K31/7048A61P9/10C07H1/08C07H17/07
Inventor 邵旭
Owner 安徽九方制药有限公司
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