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Danhong drip pill prepared from salvia root and carthamus and its preparation method

A technology of salvia miltiorrhiza and safflower, which is applied in the direction of pill delivery, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of long dissolution time, heavy financial burden on patients, and low dissolution rate, so as to avoid gastrointestinal Effects of stimulating symptoms, improving bioavailability, accelerating dissolution and absorption

Inactive Publication Date: 2005-10-26
张睿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the limitations of existing injection preparation technology and the influence of the complexity of traditional Chinese medicine ingredients, traditional Chinese medicine injections are often prone to acute allergic reactions or adverse reactions. At the same time, there are also difficulties in operation, great pain for patients, high manufacturing and medical costs, and inconvenient transportation and storage. , heavy economic burden for patients, unsuitable for family use and other disadvantages
[0008] In addition, due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the drug efficacy. The play also directly affects the therapeutic effect
At the same time, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] Now with several groups of specific examples, the preparation method of Danhong dripping pills of the present invention will be further described.

[0031] [Group 1: Trials with a single substrate]

[0032] 1. Raw materials: according to the preparation method 1, the dry powder containing the active pharmaceutical ingredients of the traditional Chinese medicine salvia miltiorrhiza and safflower is pre-prepared for use;

[0033] 2. Substrate: polyethylene glycol (1000、2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc.;

[0034] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0035] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain Danhong Dropping Pills of different specifications.

[0036] [test results]

[0037] Test 1: In order to observe the differ...

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PUM

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Abstract

A Chinese medicine in the form of dripping pill for treating apoplexy, coronary heart disease, angena pectoris, myocardiac infarction, ischemic cerebral disease, cerebral thrombus, etc is prepared from red sage root, safflower and medicinal carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a kind of blood circulation promoting and blood stasis dispelling, dredging the meridians and relaxing collaterals, which is used for treating chest obstruction and stroke caused by blood stasis, coronary heart disease, angina pectoris, myocardial infarction, blood stasis type cor pulmonale, ischemic encephalopathy, cerebral palsy, etc. The pharmaceutical composition for diseases such as thrombosis, in particular relates to a pharmaceutical composition oral preparation prepared from traditional Chinese medicine salvia miltiorrhiza and safflower as raw materials and a pharmaceutically acceptable carrier as a matrix. Background technique [0002] Danhong Injection, which is prepared according to the formula and extraction process given in the national drug standard WS-11221 (ZD-1221)-2002, is a medicine used to treat chest pain and stroke caused by blood stasis. (Syndrome: chest pain, chest tightness, palpitations, crooked mouth ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 曲韵智
Owner 张睿
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