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Anti entity tumour medicinal composition containing platinum compound

A technology of tumor drugs and compositions, which is applied in the field of drugs, and can solve the problems of difficult tumor local formation of effective drug concentration and limitations

Inactive Publication Date: 2005-10-26
DASEN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. See Kong Qingzhong "Intratumoral placement of cisplatin plus systemic carmustine in the treatment of rat brain tumors" "Journal of Surgical Oncology" 69 pages 76-82 (1998) (Kong Q et al., J Surg Oncol.1998 Oct; 69( 2): 76-82), simply increasing the dosage is limited by systemic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Put 80mg of polyglycolic acid and glycolic acid copolymer (PLGA) with a molecular weight of 10000 into the container, add 100ml of dichloromethane, dissolve and mix well, add 10mg of oxaliplatin and 10mg of mitomycin C, and re Shake well and vacuum dry to remove organic solvents. The dried solid composition is immediately shaped, and then irradiated to sterilize it after packaging to obtain an anti-solid tumor pharmaceutical composition containing 10% oxaliplatin and 10% mitomycin C. All are percentages by weight. The drug release time of the anti-solid tumor drug composition in vitro in physiological saline is 15-20 days, and the drug release time under the skin of mice is 30-40 days.

Embodiment 2

[0094] The method of processing into an anti-solid tumor pharmaceutical composition is the same as in Example 1, except that the anti-cancer active ingredients contained are:

[0095] (A) 1-50% of cisplatin, carboplatin, heptanoplatin, dinaplatin, enroplatin, epithioplatin, cisspiroplatin, dexomaplatin, isoproplatin, lobaplatin, miplatin, nedaplatin , Omaplatin, Spanplatin, Spiroplatin, Oxaliplatin or Zeniplatin and 1-50% Paclitaxel, Docetaxel, 2'-hydroxypaclitaxel, 10-Deacetylbaccatin III, 14β -Hydroxy-10-deacetylbaccatin III, 9-dihydro-13-baccatin III, IDN5109, 10-deacetylpaclitaxel, 7-epi-taxol, baccatin, berry A combination of gibberellin III or baccatin V; or

[0096] (B) 1-50% cisplatin, carboplatin, heptanoplatin, dinaplatin, enroplatin, epithioplatin, cisspiroplatin, dexomaplatin, isoproplatin, lobaplatin, miplatin, nedaplatin , Omaplatin, Spanplatin, Spiroplatin, Oxaliplatin or Zeniplatin and 1-50% Bleomycin, Daunorubicin, Arubicin, Doxorubicin, Epirubicin, Pirubicin Comb...

Embodiment 3

[0099] Put 80mg of a copolymer of polyglycolic acid and glycolic acid (PLGA) with a molecular weight of 20,000 into a container, add 100ml of dichloromethane, dissolve and mix well, add 10mg of cisplatin and 10mg of doxorubicin, shake again and vacuum Dry to remove organic solvents. The dried solid composition is immediately shaped, and then irradiated after being dispensed to obtain an anti-solid tumor pharmaceutical composition containing 10% cisplatin and 10% doxorubicin. All are percentages by weight. The drug release time of the anti-solid tumor drug composition in vitro in physiological saline is 15-20 days, and the drug release time under the skin of mice is 30-40 days.

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PUM

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Abstract

A composite medicine for treating solid tumor by locally putting it in the tumor is composed of the active anticancer components (Pt compound and its synergist choosen from taxol-type anticancer medicine, antineoplastic antibiotic and antimetabolitic medicine), and the medicinal auxiliary (biocompatible and biodegradable high-molecular polymer).

Description

(1) Technical field [0001] The invention relates to an anti-solid tumor pharmaceutical composition, which belongs to the technical field of medicine. (2) Background technology [0002] The treatment of cancer mainly includes surgery, radiotherapy and chemotherapy. Among the various chemotherapeutics used, platinum compounds have obvious effects and have been widely used in a variety of malignant tumors. Since platinum compounds exert their anti-tumor effect by inhibiting RNA synthesis by binding to DNA, and the DNA repair function in many tumor cells is significantly increased after treatment, it is becoming effective to reduce or inhibit the DNA repair function in tumor cells. The focus of current research. [0003] Recently, it has been discovered that inactivating or inhibiting DNA repair proteins in cells can enhance the sensitivity of some tumor cells to chemotherapy. See Duolan et al. "The cytotoxic sensitivity of 06-benzylguanine analogues to alkylating agents in human tum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/08
Inventor 孔庆忠孙娟宋邦强左昌儒
Owner DASEN BIOLOGICAL PHARMA CO LTD
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